9ant: Difference between revisions

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[[Image:9ant.gif|left|200px]]<br /><applet load="9ant" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:9ant.gif|left|200px]]<br /><applet load="9ant" size="350" color="white" frame="true" align="right" spinBox="true"

caption="9ant, resolution 2.40Å" />

'''ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX'''<br />

==Overview==

Homeodomains are one of the key families of eukaryotic DNA-binding motifs, and provide an important model system for studying protein-DNA, interactions. We have crystallized the Antennapedia homeodomain-DNA, complex and solved this structure at 2.4 A resolution. NMR and molecular, dynamics studies had implied that this homeodomain achieves specificity, through an ensemble of rapidly fluctuating DNA contacts. The crystal, structure is in agreement with the underlying NMR data, but our structure, reveals a well-defined set of contacts and also reveals the locations and, roles of water molecules at the protein-DNA interface. The synthesis of, X-ray and NMR studies provides a unified, general model for, homeodomain-DNA interactions.

Homeodomains are one of the key families of eukaryotic DNA-binding motifs and provide an important model system for studying protein-DNA interactions. We have crystallized the Antennapedia homeodomain-DNA complex and solved this structure at 2.4 A resolution. NMR and molecular dynamics studies had implied that this homeodomain achieves specificity through an ensemble of rapidly fluctuating DNA contacts. The crystal structure is in agreement with the underlying NMR data, but our structure reveals a well-defined set of contacts and also reveals the locations and roles of water molecules at the protein-DNA interface. The synthesis of X-ray and NMR studies provides a unified, general model for homeodomain-DNA interactions.

==About this Structure==

9ANT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with NI as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=9ANT OCA].

9ANT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with <scene name='pdbligand=NI:'>NI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ANT OCA].

==Reference==

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[[Category: Single protein]]

[[Category: Fraenkel, E.]]

[[Category: Pabo, C.O.]]

[[Category: Pabo, C O.]]

[[Category: NI]]

[[Category: complex (homeodomain/dna)]]

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[[Category: homeodomain]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:18:26 2008''

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@@ Line 1: / Line 1: @@
-[[Image:9ant.gif|left|200px]]<br /><applet load="9ant" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:9ant.gif|left|200px]]<br /><applet load="9ant" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="9ant, resolution 2.40&Aring;" />
 '''ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX'''<br />
 ==Overview==
-Homeodomains are one of the key families of eukaryotic DNA-binding motifs, and provide an important model system for studying protein-DNA, interactions. We have crystallized the Antennapedia homeodomain-DNA, complex and solved this structure at 2.4 A resolution. NMR and molecular, dynamics studies had implied that this homeodomain achieves specificity, through an ensemble of rapidly fluctuating DNA contacts. The crystal, structure is in agreement with the underlying NMR data, but our structure, reveals a well-defined set of contacts and also reveals the locations and, roles of water molecules at the protein-DNA interface. The synthesis of, X-ray and NMR studies provides a unified, general model for, homeodomain-DNA interactions.
+Homeodomains are one of the key families of eukaryotic DNA-binding motifs and provide an important model system for studying protein-DNA interactions. We have crystallized the Antennapedia homeodomain-DNA complex and solved this structure at 2.4 A resolution. NMR and molecular dynamics studies had implied that this homeodomain achieves specificity through an ensemble of rapidly fluctuating DNA contacts. The crystal structure is in agreement with the underlying NMR data, but our structure reveals a well-defined set of contacts and also reveals the locations and roles of water molecules at the protein-DNA interface. The synthesis of X-ray and NMR studies provides a unified, general model for homeodomain-DNA interactions.
 ==About this Structure==
-ANT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with NI as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=9ANT OCA].
+ANT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with <scene name='pdbligand=NI:'>NI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ANT OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Fraenkel, E.]]
-[[Category: Pabo, C.O.]]
+[[Category: Pabo, C O.]]
 [[Category: NI]]
 [[Category: complex (homeodomain/dna)]]
@@ Line 20: / Line 20: @@
 [[Category: homeodomain]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:02:13 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:18:26 2008''