9gpb: Difference between revisions
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New page: left|200px<br /><applet load="9gpb" size="450" color="white" frame="true" align="right" spinBox="true" caption="9gpb, resolution 2.9Å" /> '''THE ALLOSTERIC TRANSI... |
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[[Image:9gpb.gif|left|200px]]<br /><applet load="9gpb" size=" | [[Image:9gpb.gif|left|200px]]<br /><applet load="9gpb" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="9gpb, resolution 2.9Å" /> | caption="9gpb, resolution 2.9Å" /> | ||
'''THE ALLOSTERIC TRANSITION OF GLYCOGEN PHOSPHORYLASE'''<br /> | '''THE ALLOSTERIC TRANSITION OF GLYCOGEN PHOSPHORYLASE'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of R-state glycogen phosphorylase b has been | The crystal structure of R-state glycogen phosphorylase b has been determined at 2.9 A resolution. A comparison of T-state and R-state structures of the enzyme explains its cooperative behaviour on ligand binding and the allosteric regulation of its activity. Communication between catalytic sites of the dimer is provided by a change in packing geometry of two helices linking each site with the subunit interface. Activation by AMP or by phosphorylation results in a quaternary conformational change that switches these two helices into the R-state conformation. | ||
==About this Structure== | ==About this Structure== | ||
9GPB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with SO4 and PLP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] Full crystallographic information is available from [http:// | 9GPB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=PLP:'>PLP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GPB OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Barford, D.]] | [[Category: Barford, D.]] | ||
[[Category: Johnson, L | [[Category: Johnson, L N.]] | ||
[[Category: PLP]] | [[Category: PLP]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: glycogen phosphorylase]] | [[Category: glycogen phosphorylase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:18:30 2008'' | ||
