1den: Difference between revisions

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[[Image:1den.gif|left|200px]]<br /><applet load="1den" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1den.gif|left|200px]]<br /><applet load="1den" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1den" />

'''PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS'''<br />

==Overview==

We report here the NMR structure of dendrotoxin I, a powerful potassium, channel blocker from the venom of the African Elapidae snake Dendroaspis, polylepis polylepis (black mamba), calculated from an, experimentally-derived set of 719 geometric restraints. The backbone of, the toxin superimposes on bovine pancreatic trypsin inhibitor (BPTI) with, a root-mean-square deviation of < 1.7 A. The surface electrostatic, potential calculated for dendrotoxin I and BPTI, reveal an important, difference which might account for the differences in function of the two, proteins. These proteins may provide examples of adaptation for specific, and diverse biological functions while at the same time maintaining the, overall three-dimensional structure of a common ancestor.

We report here the NMR structure of dendrotoxin I, a powerful potassium channel blocker from the venom of the African Elapidae snake Dendroaspis polylepis polylepis (black mamba), calculated from an experimentally-derived set of 719 geometric restraints. The backbone of the toxin superimposes on bovine pancreatic trypsin inhibitor (BPTI) with a root-mean-square deviation of < 1.7 A. The surface electrostatic potential calculated for dendrotoxin I and BPTI, reveal an important difference which might account for the differences in function of the two proteins. These proteins may provide examples of adaptation for specific and diverse biological functions while at the same time maintaining the overall three-dimensional structure of a common ancestor.

==About this Structure==

1DEN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1DEN OCA].

1DEN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEN OCA].

==Reference==

Line 13:

[[Category: Dendroaspis polylepis polylepis]]

[[Category: Single protein]]

[[Category: Foray, M.F.]]

[[Category: Foray, M F.]]

[[Category: Lancelin, J.M.]]

[[Category: Lancelin, J M.]]

[[Category: venom(potassium channel inhibitor)]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 13~~:13:~~24 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:15:52 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1den.gif|left|200px]]<br /><applet load="1den" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1den.gif|left|200px]]<br /><applet load="1den" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1den" />
 '''PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS'''<br />
 ==Overview==
-We report here the NMR structure of dendrotoxin I, a powerful potassium, channel blocker from the venom of the African Elapidae snake Dendroaspis, polylepis polylepis (black mamba), calculated from an, experimentally-derived set of 719 geometric restraints. The backbone of, the toxin superimposes on bovine pancreatic trypsin inhibitor (BPTI) with, a root-mean-square deviation of &lt; 1.7 A. The surface electrostatic, potential calculated for dendrotoxin I and BPTI, reveal an important, difference which might account for the differences in function of the two, proteins. These proteins may provide examples of adaptation for specific, and diverse biological functions while at the same time maintaining the, overall three-dimensional structure of a common ancestor.
+We report here the NMR structure of dendrotoxin I, a powerful potassium channel blocker from the venom of the African Elapidae snake Dendroaspis polylepis polylepis (black mamba), calculated from an experimentally-derived set of 719 geometric restraints. The backbone of the toxin superimposes on bovine pancreatic trypsin inhibitor (BPTI) with a root-mean-square deviation of &lt; 1.7 A. The surface electrostatic potential calculated for dendrotoxin I and BPTI, reveal an important difference which might account for the differences in function of the two proteins. These proteins may provide examples of adaptation for specific and diverse biological functions while at the same time maintaining the overall three-dimensional structure of a common ancestor.
 ==About this Structure==
-DEN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DEN OCA].
+DEN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEN OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Dendroaspis polylepis polylepis]]
 [[Category: Single protein]]
-[[Category: Foray, M.F.]]
+[[Category: Foray, M F.]]
-[[Category: Lancelin, J.M.]]
+[[Category: Lancelin, J M.]]
 [[Category: venom(potassium channel inhibitor)]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:13:24 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:15:52 2008''