1dfq: Difference between revisions
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New page: left|200px<br /><applet load="1dfq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dfq, resolution 2.60Å" /> '''THE HC FRAGMENT OF T... |
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[[Image:1dfq.gif|left|200px]]<br /><applet load="1dfq" size=" | [[Image:1dfq.gif|left|200px]]<br /><applet load="1dfq" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1dfq, resolution 2.60Å" /> | caption="1dfq, resolution 2.60Å" /> | ||
'''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID'''<br /> | '''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID'''<br /> | ||
==Overview== | ==Overview== | ||
The entry of tetanus neurotoxin into neuronal cells proceeds through the | The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding. | ||
==About this Structure== | ==About this Structure== | ||
1DFQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with SLB as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] Full crystallographic information is available from [http:// | 1DFQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with <scene name='pdbligand=SLB:'>SLB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFQ OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Tentoxilysin]] | [[Category: Tentoxilysin]] | ||
[[Category: Black, I.]] | [[Category: Black, I.]] | ||
[[Category: Charles, I | [[Category: Charles, I G.]] | ||
[[Category: Emsley, P.]] | [[Category: Emsley, P.]] | ||
[[Category: Fairweather, N | [[Category: Fairweather, N F.]] | ||
[[Category: Fotinou, C.]] | [[Category: Fotinou, C.]] | ||
[[Category: Hewitt, E.]] | [[Category: Hewitt, E.]] | ||
[[Category: Isaacs, N | [[Category: Isaacs, N W.]] | ||
[[Category: Watts, C.]] | [[Category: Watts, C.]] | ||
[[Category: SLB]] | [[Category: SLB]] | ||
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[[Category: toxin]] | [[Category: toxin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:16:15 2008'' | ||
