1dj8: Difference between revisions

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[[Image:1dj8.jpg|left|200px]]<br /><applet load="1dj8" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1dj8.jpg|left|200px]]<br /><applet load="1dj8" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1dj8, resolution 2.0Å" />

'''CRYSTAL STRUCTURE OF E. COLI PERIPLASMIC PROTEIN HDEA'''<br />

==Overview==

The X-ray crystal structure of the Escherichia coli stress response, protein HDEA has been determined at 2.0 A resolution. The single domain, alpha-helical protein is found in the periplasmic space, where it supports, an acid resistance phenotype essential for infectivity of enteric, bacterial pathogens, such as Shigella and E. coli. Functional studies, demonstrate that HDEA is activated by a dimer-to-monomer transition at, acidic pH, leading to suppression of aggregation by acid-denatured, proteins. We suggest that HDEA may support chaperone-like functions during, the extremely acidic conditions.

The X-ray crystal structure of the Escherichia coli stress response protein HDEA has been determined at 2.0 A resolution. The single domain alpha-helical protein is found in the periplasmic space, where it supports an acid resistance phenotype essential for infectivity of enteric bacterial pathogens, such as Shigella and E. coli. Functional studies demonstrate that HDEA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. We suggest that HDEA may support chaperone-like functions during the extremely acidic conditions.

==About this Structure==

1DJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1DJ8 OCA].

1DJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJ8 OCA].

==Reference==

Line 13:

[[Category: Escherichia coli]]

[[Category: Single protein]]

[[Category: Burley, S.K.]]

[[Category: Burley, S K.]]

[[Category: Gajiwala, K.S.]]

[[Category: Gajiwala, K S.]]

[[Category: alpha helical]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 13~~:19:~~30 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:17:06 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1dj8.jpg|left|200px]]<br /><applet load="1dj8" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1dj8.jpg|left|200px]]<br /><applet load="1dj8" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1dj8, resolution 2.0&Aring;" />
 '''CRYSTAL STRUCTURE OF E. COLI PERIPLASMIC PROTEIN HDEA'''<br />
 ==Overview==
-The X-ray crystal structure of the Escherichia coli stress response, protein HDEA has been determined at 2.0 A resolution. The single domain, alpha-helical protein is found in the periplasmic space, where it supports, an acid resistance phenotype essential for infectivity of enteric, bacterial pathogens, such as Shigella and E. coli. Functional studies, demonstrate that HDEA is activated by a dimer-to-monomer transition at, acidic pH, leading to suppression of aggregation by acid-denatured, proteins. We suggest that HDEA may support chaperone-like functions during, the extremely acidic conditions.
+The X-ray crystal structure of the Escherichia coli stress response protein HDEA has been determined at 2.0 A resolution. The single domain alpha-helical protein is found in the periplasmic space, where it supports an acid resistance phenotype essential for infectivity of enteric bacterial pathogens, such as Shigella and E. coli. Functional studies demonstrate that HDEA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. We suggest that HDEA may support chaperone-like functions during the extremely acidic conditions.
 ==About this Structure==
-DJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DJ8 OCA].
+DJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJ8 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Escherichia coli]]
 [[Category: Single protein]]
-[[Category: Burley, S.K.]]
+[[Category: Burley, S K.]]
-[[Category: Gajiwala, K.S.]]
+[[Category: Gajiwala, K S.]]
 [[Category: alpha helical]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:19:30 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:17:06 2008''