Temperature value: Difference between revisions

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In crystallography, '''uncertainty''' in the positions of atoms increases with ''disorder'' in the protein crystal. Disorder may have two components, static and dynamic. First, some regions of the molecule may adopt different conformations in different copies of the molecule, each molecule's conformation being stable (static disorder). Second, some regions of every copy of the molecule may be subject to thermal motion, meaning vibration about the rest position<ref>[http://www.elsevier.com/wps/product/cws_home/707331 Rhodes, G. 2006. Crystallography Made Crystal Clear, 3rd ed. Academic Press.]</ref> Thermal motion is minimized when the crystal is frozen with liquid nitrogen while being irradiated, but irradiation may warm the crystal permitting some thermal motion.

In crystallography, '''uncertainty''' in the positions of atoms increases with '''disorder''' in the protein crystal. Disorder may have two components, static and dynamic. First, some regions of the molecule may adopt different conformations in different copies of the molecule, each molecule's conformation being stable (static disorder). Second, some regions of every copy of the molecule may be subject to thermal motion, meaning vibration about the rest position<ref>[http://www.elsevier.com/wps/product/cws_home/707331 Rhodes, G. 2006. Crystallography Made Crystal Clear, 3rd ed. Academic Press.]</ref> Thermal motion is minimized when the crystal is frozen with liquid nitrogen while being irradiated, but irradiation may warm the crystal permitting some thermal motion.

Some regions of the molecule may have higher average disorder, and others lower average disorder. Typically, the ends of chains have higher average disorder, and hence their positions are less certain than are residues in the core of a tightly packed domain, where disorder is less.

Temperature value: Difference between revisions

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Revision as of 00:24, 27 June 2008 view source Eric Martz (talk \| contribs) ConfirmAccount, Editor, Print3D, Tester, Bureaucrats, journal, Administrators 30,128 edits adding content ← Older edit		Revision as of 00:34, 27 June 2008 view source Eric Martz (talk \| contribs) ConfirmAccount, Editor, Print3D, Tester, Bureaucrats, journal, Administrators 30,128 edits polishing Newer edit →
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	In crystallography, '''uncertainty''' in the positions of atoms increases with ''disorder'' in the protein crystal. Disorder may have two components, static and dynamic. First, some regions of the molecule may adopt different conformations in different copies of the molecule, each molecule's conformation being stable (static disorder). Second, some regions of every copy of the molecule may be subject to thermal motion, meaning vibration about the rest position<ref>[http://www.elsevier.com/wps/product/cws_home/707331 Rhodes, G. 2006. Crystallography Made Crystal Clear, 3rd ed. Academic Press.]</ref> Thermal motion is minimized when the crystal is frozen with liquid nitrogen while being irradiated, but irradiation may warm the crystal permitting some thermal motion.		In crystallography, '''uncertainty''' in the positions of atoms increases with '''disorder''' in the protein crystal. Disorder may have two components, static and dynamic. First, some regions of the molecule may adopt different conformations in different copies of the molecule, each molecule's conformation being stable (static disorder). Second, some regions of every copy of the molecule may be subject to thermal motion, meaning vibration about the rest position<ref>[http://www.elsevier.com/wps/product/cws_home/707331 Rhodes, G. 2006. Crystallography Made Crystal Clear, 3rd ed. Academic Press.]</ref> Thermal motion is minimized when the crystal is frozen with liquid nitrogen while being irradiated, but irradiation may warm the crystal permitting some thermal motion.

	Some regions of the molecule may have higher average disorder, and others lower average disorder. Typically, the ends of chains have higher average disorder, and hence their positions are less certain than are residues in the core of a tightly packed domain, where disorder is less.		Some regions of the molecule may have higher average disorder, and others lower average disorder. Typically, the ends of chains have higher average disorder, and hence their positions are less certain than are residues in the core of a tightly packed domain, where disorder is less.