1drs: Difference between revisions

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[[Image:1drs.gif|left|200px]]<br /><applet load="1drs" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1drs.gif|left|200px]]<br /><applet load="1drs" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1drs" />

'''THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN'''<br />

==Overview==

Dendroaspin is a short chain neurotoxin homologue from the venom of, Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it, contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of, platelet aggregation and platelet adhesion with comparable potency to the, disintegrins from the venoms of Viperidae. We have determined the, structure of dendroaspin in solution using NMR spectroscopy. The structure, contains a core similar to that of short chain neurotoxins, but with a, novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is, thus an integrin antagonist with a well defined fold different from that, of the disintegrins, based on the neurotoxin scaffold.

Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold.

==About this Structure==

1DRS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA].

1DRS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA].

==Reference==

Line 13:

[[Category: Dendroaspis jamesoni kaimosae]]

[[Category: Single protein]]

[[Category: Hyde, E.I.]]

[[Category: Hyde, E I.]]

[[Category: Jaseja, M.]]

[[Category: Lu, X.]]

[[Category: Sutcliffe, M.J.]]

[[Category: Sutcliffe, M J.]]

[[Category: Williams, J.A.]]

[[Category: Williams, J A.]]

[[Category: cell adhesion protein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 13~~:31:~~53 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:44 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1drs.gif|left|200px]]<br /><applet load="1drs" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1drs.gif|left|200px]]<br /><applet load="1drs" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1drs" />
 '''THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN'''<br />
 ==Overview==
-Dendroaspin is a short chain neurotoxin homologue from the venom of, Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it, contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of, platelet aggregation and platelet adhesion with comparable potency to the, disintegrins from the venoms of Viperidae. We have determined the, structure of dendroaspin in solution using NMR spectroscopy. The structure, contains a core similar to that of short chain neurotoxins, but with a, novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is, thus an integrin antagonist with a well defined fold different from that, of the disintegrins, based on the neurotoxin scaffold.
+Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold.
 ==About this Structure==
-DRS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA].
+DRS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Dendroaspis jamesoni kaimosae]]
 [[Category: Single protein]]
-[[Category: Hyde, E.I.]]
+[[Category: Hyde, E I.]]
 [[Category: Jaseja, M.]]
 [[Category: Lu, X.]]
-[[Category: Sutcliffe, M.J.]]
+[[Category: Sutcliffe, M J.]]
-[[Category: Williams, J.A.]]
+[[Category: Williams, J A.]]
 [[Category: cell adhesion protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:31:53 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:44 2008''