1dvi: Difference between revisions
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New page: left|200px<br /><applet load="1dvi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dvi, resolution 2.30Å" /> '''CALPAIN DOMAIN VI WI... |
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[[Image:1dvi.gif|left|200px]]<br /><applet load="1dvi" size=" | [[Image:1dvi.gif|left|200px]]<br /><applet load="1dvi" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1dvi, resolution 2.30Å" /> | caption="1dvi, resolution 2.30Å" /> | ||
'''CALPAIN DOMAIN VI WITH CALCIUM BOUND'''<br /> | '''CALPAIN DOMAIN VI WITH CALCIUM BOUND'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of a Ca(2+)-binding domain (dVI) of rat m-calpain | The crystal structure of a Ca(2+)-binding domain (dVI) of rat m-calpain has been determined at 2.3 A resolution, both with and without bound Ca2+. The structures reveal a unique fold incorporating five EF-hand motifs per monomer, three of which bind calcium at physiological calcium concentrations, with one showing a novel EF-hand coordination pattern. This investigation gives us a first view of the calcium-induced conformational changes, and consequently an insight into the mechanism of calcium induced activation in calpain. The crystal structures reveal a dVI homodimer which provides a preliminary model for the subunit dimerization in calpain. | ||
==About this Structure== | ==About this Structure== | ||
1DVI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 and 3.4.22.53 3.4.22.52 and 3.4.22.53] Full crystallographic information is available from [http:// | 1DVI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 and 3.4.22.53 3.4.22.52 and 3.4.22.53] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DVI OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: small subunit]] | [[Category: small subunit]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:20:56 2008'' | ||
