1epf: Difference between revisions

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[[Image:1epf.gif|left|200px]]<br /><applet load="1epf" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1epf.gif|left|200px]]<br /><applet load="1epf" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1epf, resolution 1.85Å" />

'''CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)'''<br />

==Overview==

The neural cell adhesion molecule NCAM, a member of the immunoglobulin, superfamily, mediates cell-cell recognition and adhesion via a homophilic, interaction. NCAM plays a key role during development and regeneration of, the nervous system and is involved in synaptic plasticity associated with, memory and learning. The 1.85 A crystal structure of the two N-terminal, extracellular domains of NCAM reported here provides a structural basis, for the homophilic interaction. The molecular packing of the two-domain, structure reveals a cross shaped antiparallel dimer, and provides, fundamental insight into trans-cellular recognition mediated by NCAM.

The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.

==About this Structure==

1EPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA].

1EPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA].

==Reference==

Line 16:

[[Category: Bock, E.]]

[[Category: Ikemizu, S.]]

[[Category: Jones, E.Y.]]

[[Category: Jones, E Y.]]

[[Category: Kasper, C.]]

[[Category: Kastrup, J.S.]]

[[Category: Kastrup, J S.]]

[[Category: Larsen, I.K.]]

[[Category: Larsen, I K.]]

[[Category: Rasmussen, H.]]

[[Category: CA]]

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[[Category: ncam]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 14~~:12:~~00 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:16 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1epf.gif|left|200px]]<br /><applet load="1epf" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1epf.gif|left|200px]]<br /><applet load="1epf" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1epf, resolution 1.85&Aring;" />
 '''CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)'''<br />
 ==Overview==
-The neural cell adhesion molecule NCAM, a member of the immunoglobulin, superfamily, mediates cell-cell recognition and adhesion via a homophilic, interaction. NCAM plays a key role during development and regeneration of, the nervous system and is involved in synaptic plasticity associated with, memory and learning. The 1.85 A crystal structure of the two N-terminal, extracellular domains of NCAM reported here provides a structural basis, for the homophilic interaction. The molecular packing of the two-domain, structure reveals a cross shaped antiparallel dimer, and provides, fundamental insight into trans-cellular recognition mediated by NCAM.
+The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.
 ==About this Structure==
-EPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA].
+EPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA].
 ==Reference==
@@ Line 16: / Line 16: @@
 [[Category: Bock, E.]]
 [[Category: Ikemizu, S.]]
-[[Category: Jones, E.Y.]]
+[[Category: Jones, E Y.]]
 [[Category: Kasper, C.]]
-[[Category: Kastrup, J.S.]]
+[[Category: Kastrup, J S.]]
-[[Category: Larsen, I.K.]]
+[[Category: Larsen, I K.]]
 [[Category: Rasmussen, H.]]
 [[Category: CA]]
@@ Line 26: / Line 26: @@
 [[Category: ncam]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:12:00 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:16 2008''