1ev0: Difference between revisions

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[[Image:1ev0.jpg|left|200px]]<br /><applet load="1ev0" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1ev0.jpg|left|200px]]<br /><applet load="1ev0" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1ev0" />

'''SOLUTION STRUCTURE OF THE MINE TOPOLOGICAL SPECIFICITY DOMAIN'''<br />

==Overview==

Correct positioning of the division septum in Escherichia coli depends on, the coordinated action of the MinC, MinD and MinE proteins. Topological, specificity is conferred on the MinCD division inhibitor by MinE, which, counters MinCD activity only in the vicinity of the preferred midcell, division site. Here we report the structure of the homodimeric topological, specificity domain of Escherichia coli MinE and show that it forms a novel, alphabeta sandwich. Structure-directed mutagenesis of conserved surface, residues has enabled us to identify a spatially restricted site on the, surface of the protein that is critical for the topological specificity, function of MinE.

Correct positioning of the division septum in Escherichia coli depends on the coordinated action of the MinC, MinD and MinE proteins. Topological specificity is conferred on the MinCD division inhibitor by MinE, which counters MinCD activity only in the vicinity of the preferred midcell division site. Here we report the structure of the homodimeric topological specificity domain of Escherichia coli MinE and show that it forms a novel alphabeta sandwich. Structure-directed mutagenesis of conserved surface residues has enabled us to identify a spatially restricted site on the surface of the protein that is critical for the topological specificity function of MinE.

==About this Structure==

1EV0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1EV0 OCA].

1EV0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EV0 OCA].

==Reference==

Line 13:

[[Category: Escherichia coli]]

[[Category: Single protein]]

[[Category: King, G.F.]]

[[Category: King, G F.]]

[[Category: Maciejewski, M.W.]]

[[Category: Maciejewski, M W.]]

[[Category: Mullen, G.P.]]

[[Category: Mullen, G P.]]

[[Category: Pan, B.]]

[[Category: cell division]]

Line 23:

[[Category: topological specificity]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 14~~:20:~~23 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:31:47 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ev0.jpg|left|200px]]<br /><applet load="1ev0" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ev0.jpg|left|200px]]<br /><applet load="1ev0" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1ev0" />
 '''SOLUTION STRUCTURE OF THE MINE TOPOLOGICAL SPECIFICITY DOMAIN'''<br />
 ==Overview==
-Correct positioning of the division septum in Escherichia coli depends on, the coordinated action of the MinC, MinD and MinE proteins. Topological, specificity is conferred on the MinCD division inhibitor by MinE, which, counters MinCD activity only in the vicinity of the preferred midcell, division site. Here we report the structure of the homodimeric topological, specificity domain of Escherichia coli MinE and show that it forms a novel, alphabeta sandwich. Structure-directed mutagenesis of conserved surface, residues has enabled us to identify a spatially restricted site on the, surface of the protein that is critical for the topological specificity, function of MinE.
+Correct positioning of the division septum in Escherichia coli depends on the coordinated action of the MinC, MinD and MinE proteins. Topological specificity is conferred on the MinCD division inhibitor by MinE, which counters MinCD activity only in the vicinity of the preferred midcell division site. Here we report the structure of the homodimeric topological specificity domain of Escherichia coli MinE and show that it forms a novel alphabeta sandwich. Structure-directed mutagenesis of conserved surface residues has enabled us to identify a spatially restricted site on the surface of the protein that is critical for the topological specificity function of MinE.
 ==About this Structure==
-EV0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EV0 OCA].
+EV0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EV0 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Escherichia coli]]
 [[Category: Single protein]]
-[[Category: King, G.F.]]
+[[Category: King, G F.]]
-[[Category: Maciejewski, M.W.]]
+[[Category: Maciejewski, M W.]]
-[[Category: Mullen, G.P.]]
+[[Category: Mullen, G P.]]
 [[Category: Pan, B.]]
 [[Category: cell division]]
@@ Line 23: / Line 23: @@
 [[Category: topological specificity]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:20:23 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:31:47 2008''