1ew4: Difference between revisions

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[[Image:1ew4.gif|left|200px]]<br /><applet load="1ew4" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1ew4.gif|left|200px]]<br /><applet load="1ew4" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1ew4, resolution 1.40Å" />

'''CRYSTAL STRUCTURE OF ESCHERICHIA COLI CYAY PROTEIN REVEALS A NOVEL FOLD FOR THE FRATAXIN FAMILY'''<br />

==Overview==

Friedreich ataxia is an autosomal recessive neurodegenerative disease, caused by defects in the FRDA gene, which encodes a mitochondrial protein, called frataxin. Frataxin is evolutionarily conserved, with homologs, identified in mammals, worms, yeast, and bacteria. The CyaY proteins of, gamma-purple bacteria are believed to be closely related to the ancestor, of frataxin. In this study, we have determined the crystal structure of, the CyaY protein from Escherichia coli at 1.4-A resolution. It reveals a, protein fold consisting of a six-stranded antiparallel beta-sheet flanked, on one side by two alpha-helices. This fold is likely to be shared by all, members of the conserved frataxin family. This study also provides a, framework for the interpretation of disease-associated mutations in, frataxin and for understanding the possible functions of this protein, family.

Friedreich ataxia is an autosomal recessive neurodegenerative disease caused by defects in the FRDA gene, which encodes a mitochondrial protein called frataxin. Frataxin is evolutionarily conserved, with homologs identified in mammals, worms, yeast, and bacteria. The CyaY proteins of gamma-purple bacteria are believed to be closely related to the ancestor of frataxin. In this study, we have determined the crystal structure of the CyaY protein from Escherichia coli at 1.4-A resolution. It reveals a protein fold consisting of a six-stranded antiparallel beta-sheet flanked on one side by two alpha-helices. This fold is likely to be shared by all members of the conserved frataxin family. This study also provides a framework for the interpretation of disease-associated mutations in frataxin and for understanding the possible functions of this protein family.

==About this Structure==

1EW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1EW4 OCA].

1EW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EW4 OCA].

==Reference==

Line 14:

[[Category: Single protein]]

[[Category: Cho, S.]]

[[Category: Lee, J.Y.]]

[[Category: Lee, J Y.]]

[[Category: Lee, M.G.]]

[[Category: Lee, M G.]]

[[Category: Song, H.K.]]

[[Category: Song, H K.]]

[[Category: Suh, S.W.]]

[[Category: Suh, S W.]]

[[Category: Yang, J.K.]]

[[Category: Yang, J K.]]

[[Category: cyay]]

[[Category: frataxin family]]

Line 24:

[[Category: iron homeostasis]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 14~~:22:~~00 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:32:09 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ew4.gif|left|200px]]<br /><applet load="1ew4" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ew4.gif|left|200px]]<br /><applet load="1ew4" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1ew4, resolution 1.40&Aring;" />
 '''CRYSTAL STRUCTURE OF ESCHERICHIA COLI CYAY PROTEIN REVEALS A NOVEL FOLD FOR THE FRATAXIN FAMILY'''<br />
 ==Overview==
-Friedreich ataxia is an autosomal recessive neurodegenerative disease, caused by defects in the FRDA gene, which encodes a mitochondrial protein, called frataxin. Frataxin is evolutionarily conserved, with homologs, identified in mammals, worms, yeast, and bacteria. The CyaY proteins of, gamma-purple bacteria are believed to be closely related to the ancestor, of frataxin. In this study, we have determined the crystal structure of, the CyaY protein from Escherichia coli at 1.4-A resolution. It reveals a, protein fold consisting of a six-stranded antiparallel beta-sheet flanked, on one side by two alpha-helices. This fold is likely to be shared by all, members of the conserved frataxin family. This study also provides a, framework for the interpretation of disease-associated mutations in, frataxin and for understanding the possible functions of this protein, family.
+Friedreich ataxia is an autosomal recessive neurodegenerative disease caused by defects in the FRDA gene, which encodes a mitochondrial protein called frataxin. Frataxin is evolutionarily conserved, with homologs identified in mammals, worms, yeast, and bacteria. The CyaY proteins of gamma-purple bacteria are believed to be closely related to the ancestor of frataxin. In this study, we have determined the crystal structure of the CyaY protein from Escherichia coli at 1.4-A resolution. It reveals a protein fold consisting of a six-stranded antiparallel beta-sheet flanked on one side by two alpha-helices. This fold is likely to be shared by all members of the conserved frataxin family. This study also provides a framework for the interpretation of disease-associated mutations in frataxin and for understanding the possible functions of this protein family.
 ==About this Structure==
-EW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EW4 OCA].
+EW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EW4 OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Cho, S.]]
-[[Category: Lee, J.Y.]]
+[[Category: Lee, J Y.]]
-[[Category: Lee, M.G.]]
+[[Category: Lee, M G.]]
-[[Category: Song, H.K.]]
+[[Category: Song, H K.]]
-[[Category: Suh, S.W.]]
+[[Category: Suh, S W.]]
-[[Category: Yang, J.K.]]
+[[Category: Yang, J K.]]
 [[Category: cyay]]
 [[Category: frataxin family]]
@@ Line 24: / Line 24: @@
 [[Category: iron homeostasis]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:22:00 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:32:09 2008''