1dq8: Difference between revisions

Revision as of 02:11, 17 February 2009

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1dq8.png

1dq8, resolution 2.10Å (default scene)

Ligands:

COA, DTT, MAH

Activity:

Hydroxymethylglutaryl-CoA reductase (NADPH), with EC number 1.1.1.34

Structural annotation:
Resources:	CATH : 1Dq8A03, 1Dq8A02, 1Dq8A01, 1Dq8B02, 1Dq8B01, 1Dq8B03, 1Dq8C02, 1Dq8C01, 1Dq8C03, 1Dq8D03, 1Dq8D02, 1Dq8D01 InterPro : Ipr009023, Ipr000731, Ipr002202, Ipr004816, Ipr004554, Ipr009029 Pfam : PF00368 SCOP : d1dq8a4, d1dq8a1, d1dq8b4, d1dq8b1, d1dq8c1, d1dq8c4, d1dq8d1, d1dq8d4 UniProt : P04035

Functional annotation:
Cellular component:	membrane fraction endoplasmic reticulum endoplasmic reticulum membrane membrane peroxisome integral to membrane
Biological process:	germ cell migration lipid metabolic process cholesterol biosynthetic process gonad development sterol biosynthetic process cholesterol metabolic process lipid biosynthetic process biosynthetic process steroid biosynthetic process
Molecular function:	oxidoreductase activity hydroxymethylglutaryl-CoA reductase (NADPH) activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG AND COA

Template:ABSTRACT PUBMED 10698924

About this Structure

1DQ8 is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Istvan ES, Palnitkar M, Buchanan SK, Deisenhofer J. Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J. 2000 Mar 1;19(5):819-30. PMID:10698924 doi:10.1093/emboj/19.5.819

Page seeded by OCA on Tue Feb 17 04:11:02 2009

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Istvan ES, Palnitkar M, Buchanan SK, Deisenhofer J. Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J. 2000 Mar 1;19(5):819-30. PMID:10698924 doi:10.1093/emboj/19.5.819

@@ Line 20: / Line 20: @@
 ==About this Structure==
-DQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ8 OCA].
+DQ8 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ8 OCA].
 ==Reference==
-Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis., Istvan ES, Palnitkar M, Buchanan SK, Deisenhofer J, EMBO J. 2000 Mar 1;19(5):819-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10698924 10698924]
+<ref group="xtra">PMID:10698924</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
 [[Category: Buchanan, S K.]]
 [[Category: Deisenhofer, J.]]
@@ Line 35: / Line 34: @@
 [[Category: Oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:27:14 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:11:02 2009''

1dq8: Difference between revisions

Revision as of 02:11, 17 February 2009

COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG AND COA

About this Structure

Reference

Proteopedia Page Contributors and Editors (what is this?)

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