1h3z: Difference between revisions
New page: left|200px<br /><applet load="1h3z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h3z" /> '''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCH... |
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[[Image:1h3z.jpg|left|200px]]<br /><applet load="1h3z" size=" | [[Image:1h3z.jpg|left|200px]]<br /><applet load="1h3z" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE'''<br /> | '''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE'''<br /> | ||
==Overview== | ==Overview== | ||
The PWWP domain is a ubiquitous eukaryotic protein module characterised by | The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif. | ||
==About this Structure== | ==About this Structure== | ||
1H3Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http:// | 1H3Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Schizosaccharomyces pombe]] | [[Category: Schizosaccharomyces pombe]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Allen, M | [[Category: Allen, M D.]] | ||
[[Category: Bycroft, M.]] | [[Category: Bycroft, M.]] | ||
[[Category: Slater, L | [[Category: Slater, L M.]] | ||
[[Category: beta-barrel]] | [[Category: beta-barrel]] | ||
[[Category: chromatin]] | [[Category: chromatin]] | ||
[[Category: pwwp]] | [[Category: pwwp]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:57:10 2008'' | ||
Revision as of 10:57, 21 February 2008
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SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE
Overview
The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.
About this Structure
1H3Z is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.
Reference
Structural variation in PWWP domains., Slater LM, Allen MD, Bycroft M, J Mol Biol. 2003 Jul 11;330(3):571-6. PMID:12842472
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