1i04: Difference between revisions

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[[Image:1i04.jpg|left|200px]]<br /><applet load="1i04" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1i04.jpg|left|200px]]<br /><applet load="1i04" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1i04, resolution 2.0Å" />

'''CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN-I FROM MOUSE LIVER'''<br />

==Overview==

The mouse major urinary proteins are pheromone-binding proteins that, function as carriers of volatile effectors of mouse physiology and, behavior. Crystal structures of recombinant mouse major urinary protein-I, (MUP-I) complexed with the synthetic pheromones, 2-sec-butyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3-heptanone, have, been determined at high resolution. The purification of MUP-I from mouse, liver and a high-resolution structure of the natural isolate are also, reported. These results show the binding of 6-hydroxy-6-methyl-3-heptanone, to MUP-I, unambiguously define ligand orientations for two pheromones, within the MUP-I binding site, and suggest how different chemical classes, of pheromones can be accommodated within the MUP-I beta-barrel.

The mouse major urinary proteins are pheromone-binding proteins that function as carriers of volatile effectors of mouse physiology and behavior. Crystal structures of recombinant mouse major urinary protein-I (MUP-I) complexed with the synthetic pheromones, 2-sec-butyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3-heptanone, have been determined at high resolution. The purification of MUP-I from mouse liver and a high-resolution structure of the natural isolate are also reported. These results show the binding of 6-hydroxy-6-methyl-3-heptanone to MUP-I, unambiguously define ligand orientations for two pheromones within the MUP-I binding site, and suggest how different chemical classes of pheromones can be accommodated within the MUP-I beta-barrel.

==About this Structure==

1I04 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1I04 OCA].

1I04 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I04 OCA].

==Reference==

Line 13:

[[Category: Mus musculus]]

[[Category: Single protein]]

[[Category: Baker, L.J.]]

[[Category: Baker, L J.]]

[[Category: Mueller, H.]]

[[Category: Novotny, M.V.]]

[[Category: Novotny, M V.]]

[[Category: Timm, D.E.]]

[[Category: Timm, D E.]]

[[Category: Zidek, L.]]

[[Category: beta-barrel]]

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[[Category: pheromone]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:06:38 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1i04.jpg|left|200px]]<br /><applet load="1i04" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1i04.jpg|left|200px]]<br /><applet load="1i04" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1i04, resolution 2.0&Aring;" />
 '''CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN-I FROM MOUSE LIVER'''<br />
 ==Overview==
-The mouse major urinary proteins are pheromone-binding proteins that, function as carriers of volatile effectors of mouse physiology and, behavior. Crystal structures of recombinant mouse major urinary protein-I, (MUP-I) complexed with the synthetic pheromones, 2-sec-butyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3-heptanone, have, been determined at high resolution. The purification of MUP-I from mouse, liver and a high-resolution structure of the natural isolate are also, reported. These results show the binding of 6-hydroxy-6-methyl-3-heptanone, to MUP-I, unambiguously define ligand orientations for two pheromones, within the MUP-I binding site, and suggest how different chemical classes, of pheromones can be accommodated within the MUP-I beta-barrel.
+The mouse major urinary proteins are pheromone-binding proteins that function as carriers of volatile effectors of mouse physiology and behavior. Crystal structures of recombinant mouse major urinary protein-I (MUP-I) complexed with the synthetic pheromones, 2-sec-butyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3-heptanone, have been determined at high resolution. The purification of MUP-I from mouse liver and a high-resolution structure of the natural isolate are also reported. These results show the binding of 6-hydroxy-6-methyl-3-heptanone to MUP-I, unambiguously define ligand orientations for two pheromones within the MUP-I binding site, and suggest how different chemical classes of pheromones can be accommodated within the MUP-I beta-barrel.
 ==About this Structure==
-I04 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1I04 OCA].
+I04 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I04 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Mus musculus]]
 [[Category: Single protein]]
-[[Category: Baker, L.J.]]
+[[Category: Baker, L J.]]
 [[Category: Mueller, H.]]
-[[Category: Novotny, M.V.]]
+[[Category: Novotny, M V.]]
-[[Category: Timm, D.E.]]
+[[Category: Timm, D E.]]
 [[Category: Zidek, L.]]
 [[Category: beta-barrel]]
@@ Line 22: / Line 22: @@
 [[Category: pheromone]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:56:49 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:06:38 2008''