1i30: Difference between revisions
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New page: left|200px<br /><applet load="1i30" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i30, resolution 2.4Å" /> '''E. COLI ENOYL REDUCTA... |
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[[Image:1i30.gif|left|200px]]<br /><applet load="1i30" size=" | [[Image:1i30.gif|left|200px]]<br /><applet load="1i30" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1i30, resolution 2.4Å" /> | caption="1i30, resolution 2.4Å" /> | ||
'''E. COLI ENOYL REDUCTASE +NAD+SB385826'''<br /> | '''E. COLI ENOYL REDUCTASE +NAD+SB385826'''<br /> | ||
==Overview== | ==Overview== | ||
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and | 1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI. | ||
==About this Structure== | ==About this Structure== | ||
1I30 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with NAD and 826 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] Full crystallographic information is available from [http:// | 1I30 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=NAD:'>NAD</scene> and <scene name='pdbligand=826:'>826</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I30 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Janson, C | [[Category: Janson, C A.]] | ||
[[Category: Miller, W | [[Category: Miller, W H.]] | ||
[[Category: Payne, D | [[Category: Payne, D J.]] | ||
[[Category: Qiu, X.]] | [[Category: Qiu, X.]] | ||
[[Category: Seefeld, M | [[Category: Seefeld, M A.]] | ||
[[Category: 826]] | [[Category: 826]] | ||
[[Category: NAD]] | [[Category: NAD]] | ||
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[[Category: enoyl reductase]] | [[Category: enoyl reductase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:07:25 2008'' | ||
