1i7x: Difference between revisions

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[[Image:1i7x.gif|left|200px]]<br /><applet load="1i7x" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1i7x.gif|left|200px]]<br /><applet load="1i7x" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1i7x, resolution 3.00Å" />

'''BETA-CATENIN/E-CADHERIN COMPLEX'''<br />

==Overview==

As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the, tumor suppressor APC. We have determined the crystal structures of both, unphosphorylated and phosphorylated E-cadherin cytoplasmic domain, complexed with the arm repeat region of beta-catenin. The interaction, spans all 12 arm repeats, and features quasi-independent binding regions, that include helices which interact with both ends of the arm repeat, domain and an extended stretch of 14 residues which closely resembles a, portion of XTcf-3. Phosphorylation of E-cadherin results in interactions, with a hydrophobic patch of beta-catenin that mimics the binding of an, amphipathic XTcf-3 helix. APC contains sequences homologous to the, phosphorylated region of cadherin, and is likely to bind similarly.

As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly.

==About this Structure==

1I7X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1I7X OCA].

1I7X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7X OCA].

==Reference==

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[[Category: Mus musculus]]

[[Category: Protein complex]]

[[Category: Huber, A.H.]]

[[Category: Huber, A H.]]

[[Category: Weis, W.I.]]

[[Category: Weis, W I.]]

[[Category: armadillo repeat]]

[[Category: beta-catenin]]

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[[Category: protein-protein complex]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 17~~:08:~~12 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:08:57 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1i7x.gif|left|200px]]<br /><applet load="1i7x" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1i7x.gif|left|200px]]<br /><applet load="1i7x" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1i7x, resolution 3.00&Aring;" />
 '''BETA-CATENIN/E-CADHERIN COMPLEX'''<br />
 ==Overview==
-As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the, tumor suppressor APC. We have determined the crystal structures of both, unphosphorylated and phosphorylated E-cadherin cytoplasmic domain, complexed with the arm repeat region of beta-catenin. The interaction, spans all 12 arm repeats, and features quasi-independent binding regions, that include helices which interact with both ends of the arm repeat, domain and an extended stretch of 14 residues which closely resembles a, portion of XTcf-3. Phosphorylation of E-cadherin results in interactions, with a hydrophobic patch of beta-catenin that mimics the binding of an, amphipathic XTcf-3 helix. APC contains sequences homologous to the, phosphorylated region of cadherin, and is likely to bind similarly.
+As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly.
 ==About this Structure==
-I7X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1I7X OCA].
+I7X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7X OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Mus musculus]]
 [[Category: Protein complex]]
-[[Category: Huber, A.H.]]
+[[Category: Huber, A H.]]
-[[Category: Weis, W.I.]]
+[[Category: Weis, W I.]]
 [[Category: armadillo repeat]]
 [[Category: beta-catenin]]
@@ Line 22: / Line 22: @@
 [[Category: protein-protein complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:08:12 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:08:57 2008''