1i9w: Difference between revisions

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[[Image:1i9w.gif|left|200px]]<br /><applet load="1i9w" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1i9w.gif|left|200px]]<br /><applet load="1i9w" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1i9w, resolution 3.0Å" />

'''CRYSTAL STRUCTURE OF THE FUSION GLYCOPROTEIN E1 FROM SEMLIKI FOREST VIRUS'''<br />

==Overview==

Semliki Forest virus (SFV) has been extensively studied as a model for, analyzing entry of enveloped viruses into target cells. Here we describe, the trace of the polypeptide chain of the SFV fusion glycoprotein, E1, derived from an electron density map at 3.5 A resolution and describe its, interactions at the surface of the virus. E1 is unexpectedly similar to, the flavivirus envelope protein, with three structural domains disposed in, the same primary sequence arrangement. These results introduce a new class, of membrane fusion proteins which display lateral interactions to induce, the necessary curvature and direct budding of closed particles. The, resulting surface protein lattice is primed to cause membrane fusion when, exposed to the acidic environment of the endosome.

Semliki Forest virus (SFV) has been extensively studied as a model for analyzing entry of enveloped viruses into target cells. Here we describe the trace of the polypeptide chain of the SFV fusion glycoprotein, E1, derived from an electron density map at 3.5 A resolution and describe its interactions at the surface of the virus. E1 is unexpectedly similar to the flavivirus envelope protein, with three structural domains disposed in the same primary sequence arrangement. These results introduce a new class of membrane fusion proteins which display lateral interactions to induce the necessary curvature and direct budding of closed particles. The resulting surface protein lattice is primed to cause membrane fusion when exposed to the acidic environment of the endosome.

==About this Structure==

1I9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Semliki_forest_virus Semliki forest virus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1I9W OCA].

1I9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Semliki_forest_virus Semliki forest virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9W OCA].

==Reference==

Line 13:

[[Category: Semliki forest virus]]

[[Category: Single protein]]

[[Category: Fuller, S.D.]]

[[Category: Fuller, S D.]]

[[Category: Lescar, J.]]

[[Category: Navaza, J.]]

[[Category: Rey, F.A.]]

[[Category: Rey, F A.]]

[[Category: Roussel, A.]]

[[Category: Wengler, G.]]

[[Category: Wien, M.W.]]

[[Category: Wien, M W.]]

[[Category: envelope glycoprotein]]

[[Category: membrane fusion]]

[[Category: virus]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 17~~:12:~~09 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:32 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1i9w.gif|left|200px]]<br /><applet load="1i9w" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1i9w.gif|left|200px]]<br /><applet load="1i9w" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1i9w, resolution 3.0&Aring;" />
 '''CRYSTAL STRUCTURE OF THE FUSION GLYCOPROTEIN E1 FROM SEMLIKI FOREST VIRUS'''<br />
 ==Overview==
-Semliki Forest virus (SFV) has been extensively studied as a model for, analyzing entry of enveloped viruses into target cells. Here we describe, the trace of the polypeptide chain of the SFV fusion glycoprotein, E1, derived from an electron density map at 3.5 A resolution and describe its, interactions at the surface of the virus. E1 is unexpectedly similar to, the flavivirus envelope protein, with three structural domains disposed in, the same primary sequence arrangement. These results introduce a new class, of membrane fusion proteins which display lateral interactions to induce, the necessary curvature and direct budding of closed particles. The, resulting surface protein lattice is primed to cause membrane fusion when, exposed to the acidic environment of the endosome.
+Semliki Forest virus (SFV) has been extensively studied as a model for analyzing entry of enveloped viruses into target cells. Here we describe the trace of the polypeptide chain of the SFV fusion glycoprotein, E1, derived from an electron density map at 3.5 A resolution and describe its interactions at the surface of the virus. E1 is unexpectedly similar to the flavivirus envelope protein, with three structural domains disposed in the same primary sequence arrangement. These results introduce a new class of membrane fusion proteins which display lateral interactions to induce the necessary curvature and direct budding of closed particles. The resulting surface protein lattice is primed to cause membrane fusion when exposed to the acidic environment of the endosome.
 ==About this Structure==
-I9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Semliki_forest_virus Semliki forest virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1I9W OCA].
+I9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Semliki_forest_virus Semliki forest virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9W OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Semliki forest virus]]
 [[Category: Single protein]]
-[[Category: Fuller, S.D.]]
+[[Category: Fuller, S D.]]
 [[Category: Lescar, J.]]
 [[Category: Navaza, J.]]
-[[Category: Rey, F.A.]]
+[[Category: Rey, F A.]]
 [[Category: Roussel, A.]]
 [[Category: Wengler, G.]]
-[[Category: Wien, M.W.]]
+[[Category: Wien, M W.]]
 [[Category: envelope glycoprotein]]
 [[Category: membrane fusion]]
 [[Category: virus]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:12:09 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:32 2008''