1izz: Difference between revisions

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[[Image:1izz.jpg|left|200px]]<br /><applet load="1izz" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1izz.jpg|left|200px]]<br /><applet load="1izz" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1izz, resolution 2.31Å" />

'''Crystal structure of Hsp31'''<br />

==Overview==

Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose, members contain a conserved domain. DJ-1 is associated with autosomal, recessive early onset parkinsonism and Hsp31 is a molecular chaperone., Structural comparisons between DJ-1, Hsp31, and an Archaea protease, a, member of ThiJ/PfpI family, lead to the identification of the chaperone, activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the, comparisons provide insights into how the functional diversity is realized, in proteins that share an evolutionarily conserved domain. On the basis of, the chaperone activity the possible role of DJ-1 in the pathogenesis of, Parkinson's disease is discussed.

Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain a conserved domain. DJ-1 is associated with autosomal recessive early onset parkinsonism and Hsp31 is a molecular chaperone. Structural comparisons between DJ-1, Hsp31, and an Archaea protease, a member of ThiJ/PfpI family, lead to the identification of the chaperone activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the comparisons provide insights into how the functional diversity is realized in proteins that share an evolutionarily conserved domain. On the basis of the chaperone activity the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed.

==About this Structure==

1IZZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1IZZ OCA].

1IZZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZZ OCA].

==Reference==

Line 13:

[[Category: Escherichia coli]]

[[Category: Single protein]]

[[Category: Cha, S.S.]]

[[Category: Cha, S S.]]

[[Category: Lee, S.J.]]

[[Category: Lee, S J.]]

[[Category: alpha-beta sandwitch]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 17:~~48:52 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:17:36 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1izz.jpg|left|200px]]<br /><applet load="1izz" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1izz.jpg|left|200px]]<br /><applet load="1izz" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1izz, resolution 2.31&Aring;" />
 '''Crystal structure of Hsp31'''<br />
 ==Overview==
-Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose, members contain a conserved domain. DJ-1 is associated with autosomal, recessive early onset parkinsonism and Hsp31 is a molecular chaperone., Structural comparisons between DJ-1, Hsp31, and an Archaea protease, a, member of ThiJ/PfpI family, lead to the identification of the chaperone, activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the, comparisons provide insights into how the functional diversity is realized, in proteins that share an evolutionarily conserved domain. On the basis of, the chaperone activity the possible role of DJ-1 in the pathogenesis of, Parkinson's disease is discussed.
+Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain a conserved domain. DJ-1 is associated with autosomal recessive early onset parkinsonism and Hsp31 is a molecular chaperone. Structural comparisons between DJ-1, Hsp31, and an Archaea protease, a member of ThiJ/PfpI family, lead to the identification of the chaperone activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the comparisons provide insights into how the functional diversity is realized in proteins that share an evolutionarily conserved domain. On the basis of the chaperone activity the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed.
 ==About this Structure==
-IZZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IZZ OCA].
+IZZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZZ OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Escherichia coli]]
 [[Category: Single protein]]
-[[Category: Cha, S.S.]]
+[[Category: Cha, S S.]]
-[[Category: Lee, S.J.]]
+[[Category: Lee, S J.]]
 [[Category: alpha-beta sandwitch]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:48:52 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:17:36 2008''