1jjo: Difference between revisions

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[[Image:1jjo.gif|left|200px]]<br /><applet load="1jjo" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1jjo.gif|left|200px]]<br /><applet load="1jjo" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1jjo, resolution 3.06Å" />

'''Crystal Structure of Mouse Neuroserpin (Cleaved form)'''<br />

==Overview==

The protease inhibitor neuroserpin regulates the development of the, nervous system and its plasticity in the adult. Neuroserpins carrying the, Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe, here the structure of wild-type neuroserpin in a cleaved form. The, structure provides a basis to understand the role of the mutations in the, polymerization process. We propose that these mutations could delay the, insertion of the reactive center loop into the central beta-sheet A, an, essential step in the inhibition and possibly in the polymerization of, neuroserpin.

The protease inhibitor neuroserpin regulates the development of the nervous system and its plasticity in the adult. Neuroserpins carrying the Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe here the structure of wild-type neuroserpin in a cleaved form. The structure provides a basis to understand the role of the mutations in the polymerization process. We propose that these mutations could delay the insertion of the reactive center loop into the central beta-sheet A, an essential step in the inhibition and possibly in the polymerization of neuroserpin.

==About this Structure==

1JJO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1JJO OCA].

1JJO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJO OCA].

==Reference==

Line 14:

[[Category: Protein complex]]

[[Category: Briand, C.]]

[[Category: Gruetter, M.G.]]

[[Category: Gruetter, M G.]]

[[Category: Kozlov, S.V.]]

[[Category: Kozlov, S V.]]

[[Category: Sonderegger, P.]]

[[Category: neuronal serpin]]

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[[Category: serpin]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 18~~:19:~~41 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:23:22 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1jjo.gif|left|200px]]<br /><applet load="1jjo" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1jjo.gif|left|200px]]<br /><applet load="1jjo" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1jjo, resolution 3.06&Aring;" />
 '''Crystal Structure of Mouse Neuroserpin (Cleaved form)'''<br />
 ==Overview==
-The protease inhibitor neuroserpin regulates the development of the, nervous system and its plasticity in the adult. Neuroserpins carrying the, Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe, here the structure of wild-type neuroserpin in a cleaved form. The, structure provides a basis to understand the role of the mutations in the, polymerization process. We propose that these mutations could delay the, insertion of the reactive center loop into the central beta-sheet A, an, essential step in the inhibition and possibly in the polymerization of, neuroserpin.
+The protease inhibitor neuroserpin regulates the development of the nervous system and its plasticity in the adult. Neuroserpins carrying the Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe here the structure of wild-type neuroserpin in a cleaved form. The structure provides a basis to understand the role of the mutations in the polymerization process. We propose that these mutations could delay the insertion of the reactive center loop into the central beta-sheet A, an essential step in the inhibition and possibly in the polymerization of neuroserpin.
 ==About this Structure==
-JJO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JJO OCA].
+JJO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJO OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Protein complex]]
 [[Category: Briand, C.]]
-[[Category: Gruetter, M.G.]]
+[[Category: Gruetter, M G.]]
-[[Category: Kozlov, S.V.]]
+[[Category: Kozlov, S V.]]
 [[Category: Sonderegger, P.]]
 [[Category: neuronal serpin]]
@@ Line 21: / Line 21: @@
 [[Category: serpin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:19:41 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:23:22 2008''