1jr1: Difference between revisions
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New page: left|200px<br /><applet load="1jr1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jr1, resolution 2.6Å" /> '''Crystal structure of ... |
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[[Image:1jr1.jpg|left|200px]]<br /><applet load="1jr1" size=" | [[Image:1jr1.jpg|left|200px]]<br /><applet load="1jr1" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1jr1, resolution 2.6Å" /> | caption="1jr1, resolution 2.6Å" /> | ||
'''Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid'''<br /> | '''Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid'''<br /> | ||
==Overview== | ==Overview== | ||
The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex | The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication. MPA is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug recently approved for the treatment of allograft rejection. IMPDH comprises two domains: a core domain, which is an alpha/beta barrel and contains the active site, and a flanking domain. The complex, in combination with mutagenesis and kinetic data, provides a structural basis for understanding the mechanism of IMPDH activity and indicates that MPA inhibits IMPDH by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule. | ||
==About this Structure== | ==About this Structure== | ||
1JR1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus] with K, IMP and MOA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] Full crystallographic information is available from [http:// | 1JR1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus] with <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=IMP:'>IMP</scene> and <scene name='pdbligand=MOA:'>MOA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: IMP dehydrogenase]] | [[Category: IMP dehydrogenase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Caron, P | [[Category: Caron, P R.]] | ||
[[Category: Chambers, S | [[Category: Chambers, S P.]] | ||
[[Category: Fleming, M | [[Category: Fleming, M A.]] | ||
[[Category: Futer, O.]] | [[Category: Futer, O.]] | ||
[[Category: Murcko, M | [[Category: Murcko, M A.]] | ||
[[Category: Raybuck, S | [[Category: Raybuck, S A.]] | ||
[[Category: Sintchak, M | [[Category: Sintchak, M D.]] | ||
[[Category: Wilson, K | [[Category: Wilson, K P.]] | ||
[[Category: IMP]] | [[Category: IMP]] | ||
[[Category: K]] | [[Category: K]] | ||
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[[Category: mycophenolic acid]] | [[Category: mycophenolic acid]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:25:47 2008'' | ||
