1kn3: Difference between revisions

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[[Image:1kn3.gif|left|200px]]<br /><applet load="1kn3" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1kn3.gif|left|200px]]<br /><applet load="1kn3" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1kn3, resolution 1.80Å" />

'''Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)'''<br />

==Overview==

Proteins from the PEBP (phosphatidylethanolamine-binding protein) family, have been identified in a wide variety of species and are thought to, regulate a range of intracellular signalling cascades. The rat homologue, (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to, negatively regulate the MAP kinase pathway through formation of inhibitory, complexes with Raf-1 and MEK. The crystal structure of a new, murine, member of the PEBP family, termed mPEBP-2, has been determined. On the, basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the, mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar, in structure to other PEBP proteins from human, bovine and plant sources., Regions of distinctive sequence associated with the PEBP-2 subset are, discussed with reference to this structure.

Proteins from the PEBP (phosphatidylethanolamine-binding protein) family have been identified in a wide variety of species and are thought to regulate a range of intracellular signalling cascades. The rat homologue (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to negatively regulate the MAP kinase pathway through formation of inhibitory complexes with Raf-1 and MEK. The crystal structure of a new, murine member of the PEBP family, termed mPEBP-2, has been determined. On the basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar in structure to other PEBP proteins from human, bovine and plant sources. Regions of distinctive sequence associated with the PEBP-2 subset are discussed with reference to this structure.

==About this Structure==

1KN3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1KN3 OCA].

1KN3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN3 OCA].

==Reference==

Line 13:

[[Category: Mus musculus]]

[[Category: Single protein]]

[[Category: Banfield, M.J.]]

[[Category: Banfield, M J.]]

[[Category: Brady, R.L.]]

[[Category: Brady, R L.]]

[[Category: Simister, P.C.]]

[[Category: Simister, P C.]]

[[Category: cis-peptide]]

[[Category: phosphatidylethanolamine binding]]

[[Category: raf-1 kinase inhibitor]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 19~~:22:~~43 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:35:54 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1kn3.gif|left|200px]]<br /><applet load="1kn3" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1kn3.gif|left|200px]]<br /><applet load="1kn3" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1kn3, resolution 1.80&Aring;" />
 '''Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)'''<br />
 ==Overview==
-Proteins from the PEBP (phosphatidylethanolamine-binding protein) family, have been identified in a wide variety of species and are thought to, regulate a range of intracellular signalling cascades. The rat homologue, (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to, negatively regulate the MAP kinase pathway through formation of inhibitory, complexes with Raf-1 and MEK. The crystal structure of a new, murine, member of the PEBP family, termed mPEBP-2, has been determined. On the, basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the, mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar, in structure to other PEBP proteins from human, bovine and plant sources., Regions of distinctive sequence associated with the PEBP-2 subset are, discussed with reference to this structure.
+Proteins from the PEBP (phosphatidylethanolamine-binding protein) family have been identified in a wide variety of species and are thought to regulate a range of intracellular signalling cascades. The rat homologue (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to negatively regulate the MAP kinase pathway through formation of inhibitory complexes with Raf-1 and MEK. The crystal structure of a new, murine member of the PEBP family, termed mPEBP-2, has been determined. On the basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar in structure to other PEBP proteins from human, bovine and plant sources. Regions of distinctive sequence associated with the PEBP-2 subset are discussed with reference to this structure.
 ==About this Structure==
-KN3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KN3 OCA].
+KN3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN3 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Mus musculus]]
 [[Category: Single protein]]
-[[Category: Banfield, M.J.]]
+[[Category: Banfield, M J.]]
-[[Category: Brady, R.L.]]
+[[Category: Brady, R L.]]
-[[Category: Simister, P.C.]]
+[[Category: Simister, P C.]]
 [[Category: cis-peptide]]
 [[Category: phosphatidylethanolamine binding]]
 [[Category: raf-1 kinase inhibitor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:22:43 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:35:54 2008''