2p8s: Difference between revisions

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==About this Structure==
==About this Structure==
2P8S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8S OCA].  
2P8S is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8S OCA].  


==Reference==
==Reference==
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin., Biftu T, Scapin G, Singh S, Feng D, Becker JW, Eiermann G, He H, Lyons K, Patel S, Petrov A, Sinha-Roy R, Zhang B, Wu J, Zhang X, Doss GA, Thornberry NA, Weber AE, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3384-7. Epub 2007 Apr 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17433672 17433672]
<ref group="xtra">PMID:17433672</ref><references group="xtra"/>
[[Category: Dipeptidyl-peptidase IV]]
[[Category: Dipeptidyl-peptidase IV]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Biftu, T.]]
[[Category: Biftu, T.]]
[[Category: Scapin, G.]]
[[Category: Scapin, G.]]
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[[Category: Structure-based design]]
[[Category: Structure-based design]]


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Revision as of 15:53, 16 February 2009

File:2p8s.png

Template:STRUCTURE 2p8s

Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor

Template:ABSTRACT PUBMED 17433672

About this Structure

2P8S is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Biftu T, Scapin G, Singh S, Feng D, Becker JW, Eiermann G, He H, Lyons K, Patel S, Petrov A, Sinha-Roy R, Zhang B, Wu J, Zhang X, Doss GA, Thornberry NA, Weber AE. Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3384-7. Epub 2007 Apr 2. PMID:17433672 doi:10.1016/j.bmcl.2007.03.095

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