3ncm: Difference between revisions

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[[Image:3ncm.gif|left|200px]]<br /><applet load="3ncm" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:3ncm.gif|left|200px]]<br /><applet load="3ncm" size="350" color="white" frame="true" align="right" spinBox="true"

caption="3ncm" />

'''NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES'''<br />

==Overview==

The structure in solution of the second Ig-module fragment of residues, 117-208 of NCAM has been determined. Like the first Ig-module of residues, 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1, and module 2 interact weakly, and the binding sites of this interaction, have been identified. The two-module fragment NCAM(20-208) is a stable, dimer. Removal of the charged residues in these sites in NCAM(20-208), abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the, interactions of these charges produces one coherent binding site for the, formation of two antiparallel strands of the first two NCAM modules. This, mode of binding could be a major element in trans-cellular interactions in, neural cell adhesion.

The structure in solution of the second Ig-module fragment of residues 117-208 of NCAM has been determined. Like the first Ig-module of residues 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1 and module 2 interact weakly, and the binding sites of this interaction have been identified. The two-module fragment NCAM(20-208) is a stable dimer. Removal of the charged residues in these sites in NCAM(20-208) abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the interactions of these charges produces one coherent binding site for the formation of two antiparallel strands of the first two NCAM modules. This mode of binding could be a major element in trans-cellular interactions in neural cell adhesion.

==About this Structure==

3NCM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA].

3NCM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA].

==Reference==

Line 15:

[[Category: Berezin, V.]]

[[Category: Bock, E.]]

[[Category: Jensen, P.H.]]

[[Category: Jensen, P H.]]

[[Category: Poulsen, F.M.]]

[[Category: Poulsen, F M.]]

[[Category: Soroka, V.]]

[[Category: Thomsen, N.K.]]

[[Category: Thomsen, N K.]]

[[Category: cell adhesion]]

[[Category: glycoprotein]]

Line 27:

[[Category: neural adhesion molecule]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 19:53:~~15 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:10:25 2008''

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@@ Line 1: / Line 1: @@
-[[Image:3ncm.gif|left|200px]]<br /><applet load="3ncm" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:3ncm.gif|left|200px]]<br /><applet load="3ncm" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="3ncm" />
 '''NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES'''<br />
 ==Overview==
-The structure in solution of the second Ig-module fragment of residues, 117-208 of NCAM has been determined. Like the first Ig-module of residues, 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1, and module 2 interact weakly, and the binding sites of this interaction, have been identified. The two-module fragment NCAM(20-208) is a stable, dimer. Removal of the charged residues in these sites in NCAM(20-208), abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the, interactions of these charges produces one coherent binding site for the, formation of two antiparallel strands of the first two NCAM modules. This, mode of binding could be a major element in trans-cellular interactions in, neural cell adhesion.
+The structure in solution of the second Ig-module fragment of residues 117-208 of NCAM has been determined. Like the first Ig-module of residues 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1 and module 2 interact weakly, and the binding sites of this interaction have been identified. The two-module fragment NCAM(20-208) is a stable dimer. Removal of the charged residues in these sites in NCAM(20-208) abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the interactions of these charges produces one coherent binding site for the formation of two antiparallel strands of the first two NCAM modules. This mode of binding could be a major element in trans-cellular interactions in neural cell adhesion.
 ==About this Structure==
-NCM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA].
+NCM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA].
 ==Reference==
@@ Line 15: / Line 15: @@
 [[Category: Berezin, V.]]
 [[Category: Bock, E.]]
-[[Category: Jensen, P.H.]]
+[[Category: Jensen, P H.]]
-[[Category: Poulsen, F.M.]]
+[[Category: Poulsen, F M.]]
 [[Category: Soroka, V.]]
-[[Category: Thomsen, N.K.]]
+[[Category: Thomsen, N K.]]
 [[Category: cell adhesion]]
 [[Category: glycoprotein]]
@@ Line 27: / Line 27: @@
 [[Category: neural adhesion molecule]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:53:15 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:10:25 2008''