1lev: Difference between revisions
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New page: left|200px<br /><applet load="1lev" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lev, resolution 2.15Å" /> '''PORCINE KIDNEY FRUCT... |
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[[Image:1lev.jpg|left|200px]]<br /><applet load="1lev" size=" | [[Image:1lev.jpg|left|200px]]<br /><applet load="1lev" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1lev, resolution 2.15Å" /> | caption="1lev, resolution 2.15Å" /> | ||
'''PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR'''<br /> | '''PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR'''<br /> | ||
==Overview== | ==Overview== | ||
3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to | 3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to be an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. The compound binds at the AMP regulatory site by X-ray crystallography. This represents a new approach to inhibition of fructose 1,6-bisphosphatase and serves as a lead for further drug design. | ||
==About this Structure== | ==About this Structure== | ||
1LEV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with F6P, MN and CLI as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] Full crystallographic information is available from [http:// | 1LEV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=F6P:'>F6P</scene>, <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=CLI:'>CLI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEV OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
[[Category: Bauer, P | [[Category: Bauer, P H.]] | ||
[[Category: Carlo, A | [[Category: Carlo, A A.]] | ||
[[Category: Danley, D | [[Category: Danley, D E.]] | ||
[[Category: Hageman, D | [[Category: Hageman, D L.]] | ||
[[Category: Karam, G | [[Category: Karam, G A.]] | ||
[[Category: Mansour, M | [[Category: Mansour, M N.]] | ||
[[Category: McClure, L | [[Category: McClure, L D.]] | ||
[[Category: Pandit, J.]] | [[Category: Pandit, J.]] | ||
[[Category: Schulte, G | [[Category: Schulte, G K.]] | ||
[[Category: Treadway, J | [[Category: Treadway, J L.]] | ||
[[Category: Wang, I | [[Category: Wang, I K.]] | ||
[[Category: Wright, S | [[Category: Wright, S W.]] | ||
[[Category: CLI]] | [[Category: CLI]] | ||
[[Category: F6P]] | [[Category: F6P]] | ||
| Line 31: | Line 31: | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:44:21 2008'' | ||
