1lnz: Difference between revisions
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New page: left|200px<br /><applet load="1lnz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lnz, resolution 2.60Å" /> '''Structure of the Obg... |
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[[Image:1lnz.gif|left|200px]]<br /><applet load="1lnz" size=" | [[Image:1lnz.gif|left|200px]]<br /><applet load="1lnz" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1lnz, resolution 2.60Å" /> | caption="1lnz, resolution 2.60Å" /> | ||
'''Structure of the Obg GTP-binding protein'''<br /> | '''Structure of the Obg GTP-binding protein'''<br /> | ||
==Overview== | ==Overview== | ||
The Obg nucleotide binding protein family has been implicated in stress | The Obg nucleotide binding protein family has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to man. Members of the family contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain. Structural analysis of Bacillus subtilis Obg revealed respective domain architectures and how they are coupled through the putative switch elements of the C-terminal GTPase domain in apo and nucleotide-bound configurations. Biochemical analysis of bacterial and human Obg proteins combined with the structural observation of the ppGpp nucleotide within the Obg active sight suggest a potential role for ppGpp modulation of Obg function in B. subtilis. | ||
==About this Structure== | ==About this Structure== | ||
1LNZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with MG and G4P as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1LNZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=G4P:'>G4P</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LNZ OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Buglino, J.]] | [[Category: Buglino, J.]] | ||
[[Category: Burley, S | [[Category: Burley, S K.]] | ||
[[Category: Hakimian, P.]] | [[Category: Hakimian, P.]] | ||
[[Category: Lima, C | [[Category: Lima, C D.]] | ||
[[Category: NYSGXRC, New | [[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]] | ||
[[Category: Shen, V.]] | [[Category: Shen, V.]] | ||
[[Category: G4P]] | [[Category: G4P]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:46:47 2008'' | ||
