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==About this Structure==
==About this Structure==
3BVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BVB OCA].  
3BVB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BVB OCA].  


==Reference==
==Reference==
Effect of the active-site D25N mutation on the structure, stability and ligand binding of the mature HIV-1 protease., Sayer JM, Liu F, Ishima R, Weber IT, Louis JM, J Biol Chem. 2008 Feb 15;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18281688 18281688]
<ref group="xtra">PMID:18281688</ref><ref group="xtra">PMID:12933791</ref><ref group="xtra">PMID:16277992</ref><references group="xtra"/>
 
Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor., Ishima R, Torchia DA, Lynch SM, Gronenborn AM, Louis JM, J Biol Chem. 2003 Oct 31;278(44):43311-9. Epub 2003 Aug 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12933791 12933791]
 
Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S., Liu F, Boross PI, Wang YF, Tozser J, Louis JM, Harrison RW, Weber IT, J Mol Biol. 2005 Dec 9;354(4):789-800. Epub 2005 Oct 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16277992 16277992]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Liu, F.]]
[[Category: Liu, F.]]
[[Category: Weber, I T.]]
[[Category: Weber, I T.]]
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[[Category: Zinc-finger]]
[[Category: Zinc-finger]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:14:07 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:36:47 2009''

Revision as of 07:36, 17 February 2009

File:3bvb.png

Template:STRUCTURE 3bvb

Cystal structure of HIV-1 Active Site Mutant D25N and inhibitor Darunavir

Template:ABSTRACT PUBMED 18281688

About this Structure

3BVB is a 2 chains structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

  1. Sayer JM, Liu F, Ishima R, Weber IT, Louis JM. Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease. J Biol Chem. 2008 May 9;283(19):13459-70. Epub 2008 Feb 15. PMID:18281688 doi:10.1074/jbc.M708506200
  2. Ishima R, Torchia DA, Lynch SM, Gronenborn AM, Louis JM. Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor. J Biol Chem. 2003 Oct 31;278(44):43311-9. Epub 2003 Aug 21. PMID:12933791 doi:https://dx.doi.org/10.1074/jbc.M307549200
  3. Liu F, Boross PI, Wang YF, Tozser J, Louis JM, Harrison RW, Weber IT. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800. Epub 2005 Oct 21. PMID:16277992 doi:10.1016/j.jmb.2005.09.095

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