1mug: Difference between revisions
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New page: left|200px<br /><applet load="1mug" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mug, resolution 1.80Å" /> '''G:T/U MISMATCH-SPECI... |
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[[Image:1mug.gif|left|200px]]<br /><applet load="1mug" size=" | [[Image:1mug.gif|left|200px]]<br /><applet load="1mug" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1mug, resolution 1.80Å" /> | caption="1mug, resolution 1.80Å" /> | ||
'''G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI'''<br /> | '''G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI'''<br /> | ||
==Overview== | ==Overview== | ||
G:U mismatches resulting from deamination of cytosine are the most common | G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-stranded DNA. Recently, a biochemically distinct family of DNA repair enzymes has been identified, which excises both uracil and thymine, but only from mispairs with guanine. Crystal structures of the mismatch-specific uracil DNA-glycosylase (MUG) from E. coli, and of a DNA complex, reveal a remarkable structural and functional homology to UDGs despite low sequence identity. Details of the MUG structure explain its thymine DNA-glycosylase activity and the specificity for G:U/T mispairs, which derives from direct recognition of guanine on the complementary strand. | ||
==About this Structure== | ==About this Structure== | ||
1MUG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1MUG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUG OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Barlow, T.]] | [[Category: Barlow, T.]] | ||
[[Category: Barrett, T | [[Category: Barrett, T E.]] | ||
[[Category: Brown, T.]] | [[Category: Brown, T.]] | ||
[[Category: Jiricny, J.]] | [[Category: Jiricny, J.]] | ||
[[Category: Panayotou, G.]] | [[Category: Panayotou, G.]] | ||
[[Category: Pearl, L | [[Category: Pearl, L H.]] | ||
[[Category: Savva, R.]] | [[Category: Savva, R.]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: dna-glycosylase]] | [[Category: dna-glycosylase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:59:06 2008'' | ||
