1mzs: Difference between revisions
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New page: left|200px<br /><applet load="1mzs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mzs, resolution 2.1Å" /> '''CRYSTAL STRUCTURE OF ... |
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[[Image:1mzs.jpg|left|200px]]<br /><applet load="1mzs" size=" | [[Image:1mzs.jpg|left|200px]]<br /><applet load="1mzs" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1mzs, resolution 2.1Å" /> | caption="1mzs, resolution 2.1Å" /> | ||
'''CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic acid inhibitor'''<br /> | '''CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic acid inhibitor'''<br /> | ||
==Overview== | ==Overview== | ||
The first cocrystal structure of a bacterial FabH condensing enzyme and a | The first cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor is reported. The inhibitor was obtained by rational modification of a high throughput screening lead with the aid of a S. pneumoniae FabH homology model. This homology model was used to design analogues that would have both high affinity for the enzyme and appropriate aqueous solubility to facilitate cocrystallization studies. | ||
==About this Structure== | ==About this Structure== | ||
1MZS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with PO4 and 669 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] Full crystallographic information is available from [http:// | 1MZS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=669:'>669</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZS OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Aller, G | [[Category: Aller, G S.Van.]] | ||
[[Category: Brandt, M.]] | [[Category: Brandt, M.]] | ||
[[Category: Daines, R | [[Category: Daines, R A.]] | ||
[[Category: Head, M | [[Category: Head, M S.]] | ||
[[Category: Janson, C | [[Category: Janson, C A.]] | ||
[[Category: Konstantinidis, A | [[Category: Konstantinidis, A K.]] | ||
[[Category: Lonsdale, J | [[Category: Lonsdale, J T.]] | ||
[[Category: Pendrak, I.]] | [[Category: Pendrak, I.]] | ||
[[Category: Qui, X.]] | [[Category: Qui, X.]] | ||
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[[Category: fabh]] | [[Category: fabh]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:00:42 2008'' | ||
