1n1l: Difference between revisions

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[[Image:1n1l.jpg|left|200px]]<br /><applet load="1n1l" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1n1l.jpg|left|200px]]<br /><applet load="1n1l" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1n1l, resolution 2.60Å" />

'''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)'''<br />

==Overview==

[reaction: see text] In this, the second of two letters, we describe the, elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the, requirements for optimal substitution of the pyrrolidine and lactam, nitrogen atoms. Central to the strategy is the use of rapid iterative, synthesis in conjunction with X-ray crystal structure determination of, ligand-protein complexes.

[reaction: see text] In this, the second of two letters, we describe the elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the requirements for optimal substitution of the pyrrolidine and lactam nitrogen atoms. Central to the strategy is the use of rapid iterative synthesis in conjunction with X-ray crystal structure determination of ligand-protein complexes.

==About this Structure==

1N1L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with ZN and TRL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1N1L OCA].

1N1L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=TRL:'>TRL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1L OCA].

==Reference==

Line 13:

[[Category: Hepatitis c virus]]

[[Category: Protein complex]]

[[Category: Andrews, D.M.]]

[[Category: Andrews, D M.]]

[[Category: Chaignot, H.]]

[[Category: Coomber, B.A.]]

[[Category: Coomber, B A.]]

[[Category: Good, A.C.]]

[[Category: Good, A C.]]

[[Category: Hind, S.L.]]

[[Category: Hind, S L.]]

[[Category: Jones, P.S.]]

[[Category: Jones, P S.]]

[[Category: Mill, G.]]

[[Category: Robinson, J.E.]]

[[Category: Robinson, J E.]]

[[Category: Skarzynski, T.]]

[[Category: Slater, M.J.]]

[[Category: Slater, M J.]]

[[Category: Somers, D.O.N.]]

[[Category: Somers, D O.N.]]

[[Category: TRL]]

[[Category: ZN]]

Line 33:

[[Category: viral protein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 21:52:~~28 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:01:17 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1n1l.jpg|left|200px]]<br /><applet load="1n1l" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1n1l.jpg|left|200px]]<br /><applet load="1n1l" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1n1l, resolution 2.60&Aring;" />
 '''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)'''<br />
 ==Overview==
-[reaction: see text] In this, the second of two letters, we describe the, elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the, requirements for optimal substitution of the pyrrolidine and lactam, nitrogen atoms. Central to the strategy is the use of rapid iterative, synthesis in conjunction with X-ray crystal structure determination of, ligand-protein complexes.
+[reaction: see text] In this, the second of two letters, we describe the elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the requirements for optimal substitution of the pyrrolidine and lactam nitrogen atoms. Central to the strategy is the use of rapid iterative synthesis in conjunction with X-ray crystal structure determination of ligand-protein complexes.
 ==About this Structure==
-N1L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with ZN and TRL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N1L OCA].
+N1L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=TRL:'>TRL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1L OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Hepatitis c virus]]
 [[Category: Protein complex]]
-[[Category: Andrews, D.M.]]
+[[Category: Andrews, D M.]]
 [[Category: Chaignot, H.]]
-[[Category: Coomber, B.A.]]
+[[Category: Coomber, B A.]]
-[[Category: Good, A.C.]]
+[[Category: Good, A C.]]
-[[Category: Hind, S.L.]]
+[[Category: Hind, S L.]]
-[[Category: Jones, P.S.]]
+[[Category: Jones, P S.]]
 [[Category: Mill, G.]]
-[[Category: Robinson, J.E.]]
+[[Category: Robinson, J E.]]
 [[Category: Skarzynski, T.]]
-[[Category: Slater, M.J.]]
+[[Category: Slater, M J.]]
-[[Category: Somers, D.O.N.]]
+[[Category: Somers, D O.N.]]
 [[Category: TRL]]
 [[Category: ZN]]
@@ Line 33: / Line 33: @@
 [[Category: viral protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:52:28 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:01:17 2008''