1n4y: Difference between revisions

Line 1:

[[Image:1n4y.gif|left|200px]]<br /><applet load="1n4y" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1n4y.gif|left|200px]]<br /><applet load="1n4y" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1n4y" />

'''REFINED STRUCTURE OF KISTRIN'''<br />

==Overview==

The structure of kistrin, which is a member of a homologous family of, glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein, inhibitors of platelet aggregation, has been determined by two-dimensional, nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein, consists of a series of tightly packed loops held together by six, disulfide bonds and has almost no regular secondary structure. Kistrin has, an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for, binding to GP IIb-IIIa that is located at the apex of a long loop across, the surface of the protein.

The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.

==About this Structure==

1N4Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure ~~superseeds~~ the now removed PDB entry 1KST. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA].

1N4Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry 1KST. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA].

==Reference==

Line 13:

[[Category: Calloselasma rhodostoma]]

[[Category: Single protein]]

[[Category: Dennis, M.S.]]

[[Category: Dennis, M S.]]

[[Category: Krane, J.]]

[[Category: Krezel, A.M.]]

[[Category: Krezel, A M.]]

[[Category: Lazarus, R.A.]]

[[Category: Lazarus, R A.]]

[[Category: Wagner, G.]]

[[Category: beta]]

Line 23:

[[Category: venom]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 21:58:~~02 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:02:16 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1n4y.gif|left|200px]]<br /><applet load="1n4y" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1n4y.gif|left|200px]]<br /><applet load="1n4y" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1n4y" />
 '''REFINED STRUCTURE OF KISTRIN'''<br />
 ==Overview==
-The structure of kistrin, which is a member of a homologous family of, glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein, inhibitors of platelet aggregation, has been determined by two-dimensional, nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein, consists of a series of tightly packed loops held together by six, disulfide bonds and has almost no regular secondary structure. Kistrin has, an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for, binding to GP IIb-IIIa that is located at the apex of a long loop across, the surface of the protein.
+The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.
 ==About this Structure==
-N4Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure superseeds the now removed PDB entry 1KST. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA].
+N4Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry 1KST. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Calloselasma rhodostoma]]
 [[Category: Single protein]]
-[[Category: Dennis, M.S.]]
+[[Category: Dennis, M S.]]
 [[Category: Krane, J.]]
-[[Category: Krezel, A.M.]]
+[[Category: Krezel, A M.]]
-[[Category: Lazarus, R.A.]]
+[[Category: Lazarus, R A.]]
 [[Category: Wagner, G.]]
 [[Category: beta]]
@@ Line 23: / Line 23: @@
 [[Category: venom]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:58:02 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:02:16 2008''