1n95: Difference between revisions

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[[Image:1n95.gif|left|200px]]<br /><applet load="1n95" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1n95.gif|left|200px]]<br /><applet load="1n95" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1n95, resolution 2.3Å" />

'''Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives'''<br />

==Overview==

Inhibitors of farnesyltransferase are effective against a variety of, tumors in mouse models of cancer. Clinical trials to evaluate these agents, in humans are ongoing. In our effort to develop new farnesyltransferase, inhibitors, we have discovered a series of aryl tetrahydropyridines that, incorporate substituted glycine, phenylalanine and histidine residues. The, design, synthesis, SAR and biological properties of these compounds will, be discussed.

Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered a series of aryl tetrahydropyridines that incorporate substituted glycine, phenylalanine and histidine residues. The design, synthesis, SAR and biological properties of these compounds will be discussed.

==About this Structure==

1N95 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with ZN, HFP and FTH as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1N95 OCA].

1N95 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=HFP:'>HFP</scene> and <scene name='pdbligand=FTH:'>FTH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N95 OCA].

==Reference==

Line 14:

[[Category: Rattus norvegicus]]

[[Category: Cohen, J.]]

[[Category: Conner, S.J.O.]]

[[Category: Conner, S J.O.]]

[[Category: Gu, W.Z.]]

[[Category: Gu, W Z.]]

[[Category: Hasvold, L.]]

[[Category: II, S.L.Gwaltney.]]

[[Category: II, S L.Gwaltney.]]

[[Category: Imade, H.]]

[[Category: Li, Q.]]

[[Category: Nelson, L.T.]]

[[Category: Nelson, L T.]]

[[Category: Sullivan, G.M.]]

[[Category: Sullivan, G M.]]

[[Category: Wang, W.]]

[[Category: FTH]]

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[[Category: prenyltransferase]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:03:33 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1n95.gif|left|200px]]<br /><applet load="1n95" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1n95.gif|left|200px]]<br /><applet load="1n95" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1n95, resolution 2.3&Aring;" />
 '''Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives'''<br />
 ==Overview==
-Inhibitors of farnesyltransferase are effective against a variety of, tumors in mouse models of cancer. Clinical trials to evaluate these agents, in humans are ongoing. In our effort to develop new farnesyltransferase, inhibitors, we have discovered a series of aryl tetrahydropyridines that, incorporate substituted glycine, phenylalanine and histidine residues. The, design, synthesis, SAR and biological properties of these compounds will, be discussed.
+Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered a series of aryl tetrahydropyridines that incorporate substituted glycine, phenylalanine and histidine residues. The design, synthesis, SAR and biological properties of these compounds will be discussed.
 ==About this Structure==
-N95 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with ZN, HFP and FTH as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N95 OCA].
+N95 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=HFP:'>HFP</scene> and <scene name='pdbligand=FTH:'>FTH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N95 OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Rattus norvegicus]]
 [[Category: Cohen, J.]]
-[[Category: Conner, S.J.O.]]
+[[Category: Conner, S J.O.]]
-[[Category: Gu, W.Z.]]
+[[Category: Gu, W Z.]]
 [[Category: Hasvold, L.]]
-[[Category: II, S.L.Gwaltney.]]
+[[Category: II, S L.Gwaltney.]]
 [[Category: Imade, H.]]
 [[Category: Li, Q.]]
-[[Category: Nelson, L.T.]]
+[[Category: Nelson, L T.]]
-[[Category: Sullivan, G.M.]]
+[[Category: Sullivan, G M.]]
 [[Category: Wang, W.]]
 [[Category: FTH]]
@@ Line 30: / Line 30: @@
 [[Category: prenyltransferase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:04:07 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:03:33 2008''