1na4: Difference between revisions

Line 1:

[[Image:1na4.gif|left|200px]]<br /><applet load="1na4" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1na4.gif|left|200px]]<br /><applet load="1na4" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1na4" />

'''The structure of immature Yellow Fever virus particle'''<br />

==Overview==

Structures of prM-containing dengue and yellow fever virus particles were, determined to 16 and 25 A resolution, respectively, by cryoelectron, microscopy and image reconstruction techniques. The closely similar, structures show 60 icosahedrally organized trimeric spikes on the particle, surface. Each spike consists of three prM:E heterodimers, where E is an, envelope glycoprotein and prM is the precursor to the membrane protein M., The pre-peptide components of the prM proteins in each spike cover the, fusion peptides at the distal ends of the E glycoproteins in a manner, similar to the organization of the glycoproteins in the alphavirus spikes., Each heterodimer is associated with an E and a prM transmembrane density., These transmembrane densities represent either an EE or prMprM, antiparallel coiled coil by which each protein spans the membrane twice, leaving the C-terminus of each protein on the exterior of the viral, membrane, consistent with the predicted membrane-spanning domains of the, unprocessed polyprotein.

Structures of prM-containing dengue and yellow fever virus particles were determined to 16 and 25 A resolution, respectively, by cryoelectron microscopy and image reconstruction techniques. The closely similar structures show 60 icosahedrally organized trimeric spikes on the particle surface. Each spike consists of three prM:E heterodimers, where E is an envelope glycoprotein and prM is the precursor to the membrane protein M. The pre-peptide components of the prM proteins in each spike cover the fusion peptides at the distal ends of the E glycoproteins in a manner similar to the organization of the glycoproteins in the alphavirus spikes. Each heterodimer is associated with an E and a prM transmembrane density. These transmembrane densities represent either an EE or prMprM antiparallel coiled coil by which each protein spans the membrane twice, leaving the C-terminus of each protein on the exterior of the viral membrane, consistent with the predicted membrane-spanning domains of the unprocessed polyprotein.

==About this Structure==

1NA4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1NA4 OCA].

1NA4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA4 OCA].

==Reference==

Line 13:

[[Category: Single protein]]

[[Category: Yellow fever virus]]

[[Category: Baker, T.S.]]

[[Category: Baker, T S.]]

[[Category: Chipman, P.R.]]

[[Category: Chipman, P R.]]

[[Category: Corver, J.]]

[[Category: Kuhn, R.J.]]

[[Category: Kuhn, R J.]]

[[Category: Lenches, E.]]

[[Category: Pletnev, S.V.]]

[[Category: Pletnev, S V.]]

[[Category: Rossmann, M.G.]]

[[Category: Rossmann, M G.]]

[[Category: Sedlak, D.]]

[[Category: Strauss, J.H.]]

[[Category: Strauss, J H.]]

[[Category: Zhang, W.]]

[[Category: Zhang, Y.]]

Line 30:

[[Category: yellow fever immature virus]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 22~~:05:~~24 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:03:58 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1na4.gif|left|200px]]<br /><applet load="1na4" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1na4.gif|left|200px]]<br /><applet load="1na4" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1na4" />
 '''The structure of immature Yellow Fever virus particle'''<br />
 ==Overview==
-Structures of prM-containing dengue and yellow fever virus particles were, determined to 16 and 25 A resolution, respectively, by cryoelectron, microscopy and image reconstruction techniques. The closely similar, structures show 60 icosahedrally organized trimeric spikes on the particle, surface. Each spike consists of three prM:E heterodimers, where E is an, envelope glycoprotein and prM is the precursor to the membrane protein M., The pre-peptide components of the prM proteins in each spike cover the, fusion peptides at the distal ends of the E glycoproteins in a manner, similar to the organization of the glycoproteins in the alphavirus spikes., Each heterodimer is associated with an E and a prM transmembrane density., These transmembrane densities represent either an EE or prMprM, antiparallel coiled coil by which each protein spans the membrane twice, leaving the C-terminus of each protein on the exterior of the viral, membrane, consistent with the predicted membrane-spanning domains of the, unprocessed polyprotein.
+Structures of prM-containing dengue and yellow fever virus particles were determined to 16 and 25 A resolution, respectively, by cryoelectron microscopy and image reconstruction techniques. The closely similar structures show 60 icosahedrally organized trimeric spikes on the particle surface. Each spike consists of three prM:E heterodimers, where E is an envelope glycoprotein and prM is the precursor to the membrane protein M. The pre-peptide components of the prM proteins in each spike cover the fusion peptides at the distal ends of the E glycoproteins in a manner similar to the organization of the glycoproteins in the alphavirus spikes. Each heterodimer is associated with an E and a prM transmembrane density. These transmembrane densities represent either an EE or prMprM antiparallel coiled coil by which each protein spans the membrane twice, leaving the C-terminus of each protein on the exterior of the viral membrane, consistent with the predicted membrane-spanning domains of the unprocessed polyprotein.
 ==About this Structure==
-NA4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NA4 OCA].
+NA4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA4 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Single protein]]
 [[Category: Yellow fever virus]]
-[[Category: Baker, T.S.]]
+[[Category: Baker, T S.]]
-[[Category: Chipman, P.R.]]
+[[Category: Chipman, P R.]]
 [[Category: Corver, J.]]
-[[Category: Kuhn, R.J.]]
+[[Category: Kuhn, R J.]]
 [[Category: Lenches, E.]]
-[[Category: Pletnev, S.V.]]
+[[Category: Pletnev, S V.]]
-[[Category: Rossmann, M.G.]]
+[[Category: Rossmann, M G.]]
 [[Category: Sedlak, D.]]
-[[Category: Strauss, J.H.]]
+[[Category: Strauss, J H.]]
 [[Category: Zhang, W.]]
 [[Category: Zhang, Y.]]
@@ Line 30: / Line 30: @@
 [[Category: yellow fever immature virus]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:05:24 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:03:58 2008''