1nam: Difference between revisions

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[[Image:1nam.gif|left|200px]]<br /><applet load="1nam" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1nam.gif|left|200px]]<br /><applet load="1nam" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1nam, resolution 2.70Å" />

'''MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX'''<br />

==Overview==

T cell receptor (TCR) binding degeneracy lies at the heart of several, physiological and pathological phenomena, yet its structural basis is, poorly understood. We determined the crystal structure of a complex, involving the BM3.3 TCR and an octapeptide (VSV8) bound to the H-2K(b), major histocompatibility complex molecule at a 2.7 A resolution, and, compared it with the BM3.3 TCR bound to the H-2K(b) molecule loaded with a, peptide that has no primary sequence identity with VSV8. Comparison of, these structures showed that the BM3.3 TCR complementarity-determining, region (CDR) 3alpha could undergo rearrangements to adapt to structurally, different peptide residues. Therefore, CDR3 loop flexibility helps explain, TCR binding cross-reactivity.

T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and pathological phenomena, yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and an octapeptide (VSV8) bound to the H-2K(b) major histocompatibility complex molecule at a 2.7 A resolution, and compared it with the BM3.3 TCR bound to the H-2K(b) molecule loaded with a peptide that has no primary sequence identity with VSV8. Comparison of these structures showed that the BM3.3 TCR complementarity-determining region (CDR) 3alpha could undergo rearrangements to adapt to structurally different peptide residues. Therefore, CDR3 loop flexibility helps explain TCR binding cross-reactivity.

==About this Structure==

1NAM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1NAM OCA].

1NAM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAM OCA].

==Reference==

Line 14:

[[Category: Protein complex]]

[[Category: Darnault, C.]]

[[Category: Fontecilla-Camps, J.C.]]

[[Category: Fontecilla-Camps, J C.]]

[[Category: Gregoire, C.]]

[[Category: Housset, D.]]

Line 20:

[[Category: Malissen, B.]]

[[Category: Mazza, G.]]

[[Category: Merwe, P.A.van.der.]]

[[Category: Merwe, P A.van der.]]

[[Category: Mosser, T.]]

[[Category: Reiser, J.B.]]

[[Category: Reiser, J B.]]

[[Category: alloreactivity]]

[[Category: class i mhc]]

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[[Category: tcr-pmhc complex]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:04:00 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1nam.gif|left|200px]]<br /><applet load="1nam" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1nam.gif|left|200px]]<br /><applet load="1nam" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1nam, resolution 2.70&Aring;" />
 '''MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX'''<br />
 ==Overview==
-T cell receptor (TCR) binding degeneracy lies at the heart of several, physiological and pathological phenomena, yet its structural basis is, poorly understood. We determined the crystal structure of a complex, involving the BM3.3 TCR and an octapeptide (VSV8) bound to the H-2K(b), major histocompatibility complex molecule at a 2.7 A resolution, and, compared it with the BM3.3 TCR bound to the H-2K(b) molecule loaded with a, peptide that has no primary sequence identity with VSV8. Comparison of, these structures showed that the BM3.3 TCR complementarity-determining, region (CDR) 3alpha could undergo rearrangements to adapt to structurally, different peptide residues. Therefore, CDR3 loop flexibility helps explain, TCR binding cross-reactivity.
+T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and pathological phenomena, yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and an octapeptide (VSV8) bound to the H-2K(b) major histocompatibility complex molecule at a 2.7 A resolution, and compared it with the BM3.3 TCR bound to the H-2K(b) molecule loaded with a peptide that has no primary sequence identity with VSV8. Comparison of these structures showed that the BM3.3 TCR complementarity-determining region (CDR) 3alpha could undergo rearrangements to adapt to structurally different peptide residues. Therefore, CDR3 loop flexibility helps explain TCR binding cross-reactivity.
 ==About this Structure==
-NAM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NAM OCA].
+NAM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAM OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Protein complex]]
 [[Category: Darnault, C.]]
-[[Category: Fontecilla-Camps, J.C.]]
+[[Category: Fontecilla-Camps, J C.]]
 [[Category: Gregoire, C.]]
 [[Category: Housset, D.]]
@@ Line 20: / Line 20: @@
 [[Category: Malissen, B.]]
 [[Category: Mazza, G.]]
-[[Category: Merwe, P.A.van.der.]]
+[[Category: Merwe, P A.van der.]]
 [[Category: Mosser, T.]]
-[[Category: Reiser, J.B.]]
+[[Category: Reiser, J B.]]
 [[Category: alloreactivity]]
 [[Category: class i mhc]]
@@ Line 30: / Line 30: @@
 [[Category: tcr-pmhc complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:05:58 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:04:00 2008''