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{{Seed}}
[[Image:2fil.png|left|200px]]
[[Image:2fil.png|left|200px]]


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===Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-faT-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and 2'-Fluoroarabino-Thymidine (faT)===
===Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-faT-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and 2'-Fluoroarabino-Thymidine (faT)===


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{{ABSTRACT_PUBMED_16566588}}
{{ABSTRACT_PUBMED_16566588}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIL OCA].  
[[2fil]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIL OCA].  


==Reference==
==Reference==
2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H., Li F, Sarkhel S, Wilds CJ, Wawrzak Z, Prakash TP, Manoharan M, Egli M, Biochemistry. 2006 Apr 4;45(13):4141-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16566588 16566588]
<ref group="xtra">PMID:016566588</ref><references group="xtra"/>
[[Category: Egli, M.]]
[[Category: Egli, M.]]
[[Category: Li, F.]]
[[Category: Li, F.]]
[[Category: 2'-fluoroarabino acid]]
[[Category: 2'-fluoroarabino acid]]
[[Category: A-form dna]]
[[Category: A-form dna]]
[[Category: Dna]]
[[Category: Sugar modification]]
[[Category: Sugar modification]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:44:42 2008''

Revision as of 15:04, 14 August 2012

File:2fil.png

Template:STRUCTURE 2fil

Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-faT-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and 2'-Fluoroarabino-Thymidine (faT)

Template:ABSTRACT PUBMED 16566588

About this Structure

2fil is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Li F, Sarkhel S, Wilds CJ, Wawrzak Z, Prakash TP, Manoharan M, Egli M. 2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H. Biochemistry. 2006 Apr 4;45(13):4141-52. PMID:16566588 doi:10.1021/bi052322r

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