1nen: Difference between revisions

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[[Image:1nen.jpg|left|200px]]<br /><applet load="1nen" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1nen.jpg|left|200px]]<br /><applet load="1nen" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1nen, resolution 2.9Å" />

'''Complex II (Succinate Dehydrogenase) From E. Coli with Dinitrophenol-17 inhibitor co-crystallized at the ubiquinone binding site'''<br />

==Overview==

The structure of Escherichia coli succinate dehydrogenase (SQR), analogous, to the mitochondrial respiratory complex II, has been determined, revealing the electron transport pathway from the electron donor, succinate, to the terminal electron acceptor, ubiquinone. It was found, that the SQR redox centers are arranged in a manner that aids the, prevention of reactive oxygen species (ROS) formation at the flavin, adenine dinucleotide. This is likely to be the main reason SQR is, expressed during aerobic respiration rather than the related enzyme, fumarate reductase, which produces high levels of ROS. Furthermore, symptoms of genetic disorders associated with mitochondrial SQR mutations, may be a result of ROS formation resulting from impaired electron, transport in the enzyme.

The structure of Escherichia coli succinate dehydrogenase (SQR), analogous to the mitochondrial respiratory complex II, has been determined, revealing the electron transport pathway from the electron donor, succinate, to the terminal electron acceptor, ubiquinone. It was found that the SQR redox centers are arranged in a manner that aids the prevention of reactive oxygen species (ROS) formation at the flavin adenine dinucleotide. This is likely to be the main reason SQR is expressed during aerobic respiration rather than the related enzyme fumarate reductase, which produces high levels of ROS. Furthermore, symptoms of genetic disorders associated with mitochondrial SQR mutations may be a result of ROS formation resulting from impaired electron transport in the enzyme.

==About this Structure==

1NEN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with OAA, CA, FAD, FES, SF4, F3S, HEM, DNT, CDN and EPH as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1NEN OCA].

1NEN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=OAA:'>OAA</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=FAD:'>FAD</scene>, <scene name='pdbligand=FES:'>FES</scene>, <scene name='pdbligand=SF4:'>SF4</scene>, <scene name='pdbligand=F3S:'>F3S</scene>, <scene name='pdbligand=HEM:'>HEM</scene>, <scene name='pdbligand=DNT:'>DNT</scene>, <scene name='pdbligand=CDN:'>CDN</scene> and <scene name='pdbligand=EPH:'>EPH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEN OCA].

==Reference==

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[[Category: respiratory complex]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 22~~:11:~~38 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:05:17 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1nen.jpg|left|200px]]<br /><applet load="1nen" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1nen.jpg|left|200px]]<br /><applet load="1nen" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1nen, resolution 2.9&Aring;" />
 '''Complex II (Succinate Dehydrogenase) From E. Coli with Dinitrophenol-17 inhibitor co-crystallized at the ubiquinone binding site'''<br />
 ==Overview==
-The structure of Escherichia coli succinate dehydrogenase (SQR), analogous, to the mitochondrial respiratory complex II, has been determined, revealing the electron transport pathway from the electron donor, succinate, to the terminal electron acceptor, ubiquinone. It was found, that the SQR redox centers are arranged in a manner that aids the, prevention of reactive oxygen species (ROS) formation at the flavin, adenine dinucleotide. This is likely to be the main reason SQR is, expressed during aerobic respiration rather than the related enzyme, fumarate reductase, which produces high levels of ROS. Furthermore, symptoms of genetic disorders associated with mitochondrial SQR mutations, may be a result of ROS formation resulting from impaired electron, transport in the enzyme.
+The structure of Escherichia coli succinate dehydrogenase (SQR), analogous to the mitochondrial respiratory complex II, has been determined, revealing the electron transport pathway from the electron donor, succinate, to the terminal electron acceptor, ubiquinone. It was found that the SQR redox centers are arranged in a manner that aids the prevention of reactive oxygen species (ROS) formation at the flavin adenine dinucleotide. This is likely to be the main reason SQR is expressed during aerobic respiration rather than the related enzyme fumarate reductase, which produces high levels of ROS. Furthermore, symptoms of genetic disorders associated with mitochondrial SQR mutations may be a result of ROS formation resulting from impaired electron transport in the enzyme.
 ==About this Structure==
-NEN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with OAA, CA, FAD, FES, SF4, F3S, HEM, DNT, CDN and EPH as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NEN OCA].
+NEN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=OAA:'>OAA</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=FAD:'>FAD</scene>, <scene name='pdbligand=FES:'>FES</scene>, <scene name='pdbligand=SF4:'>SF4</scene>, <scene name='pdbligand=F3S:'>F3S</scene>, <scene name='pdbligand=HEM:'>HEM</scene>, <scene name='pdbligand=DNT:'>DNT</scene>, <scene name='pdbligand=CDN:'>CDN</scene> and <scene name='pdbligand=EPH:'>EPH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEN OCA].
 ==Reference==
@@ Line 35: / Line 35: @@
 [[Category: respiratory complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:11:38 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:05:17 2008''