1nl3: Difference between revisions

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[[Image:1nl3.gif|left|200px]]<br /><applet load="1nl3" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1nl3.gif|left|200px]]<br /><applet load="1nl3" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1nl3, resolution 2.800Å" />

'''CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM'''<br />

==Overview==

In bacteria, the majority of exported proteins are translocated by the Sec, system, which recognizes the signal sequence of a preprotein and uses ATP, and the proton motive force to mediate protein translocation across the, cytoplasmic membrane. SecA is an essential protein component of this, system, containing the molecular motor that facilitates translocation., Here we report the three-dimensional structure of the SecA protein of, Mycobacterium tuberculosis. Each subunit of the homodimer contains a, "motor" domain and a translocation domain. The structure predicts that, SecA can interact with the SecYEG pore and function as a molecular ratchet, that uses ATP hydrolysis for physical movement of the preprotein., Knowledge of this structure provides a framework for further elucidation, of the translocation process.

In bacteria, the majority of exported proteins are translocated by the Sec system, which recognizes the signal sequence of a preprotein and uses ATP and the proton motive force to mediate protein translocation across the cytoplasmic membrane. SecA is an essential protein component of this system, containing the molecular motor that facilitates translocation. Here we report the three-dimensional structure of the SecA protein of Mycobacterium tuberculosis. Each subunit of the homodimer contains a "motor" domain and a translocation domain. The structure predicts that SecA can interact with the SecYEG pore and function as a molecular ratchet that uses ATP hydrolysis for physical movement of the preprotein. Knowledge of this structure provides a framework for further elucidation of the translocation process.

==About this Structure==

1NL3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1NL3 OCA].

1NL3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NL3 OCA].

==Reference==

Line 16:

[[Category: Braunstein, M.]]

[[Category: Holzenburg, A.]]

[[Category: Jr., W.R.Jacobs.]]

[[Category: Jr., W R.Jacobs.]]

[[Category: Ronning, D.R.]]

[[Category: Ronning, D R.]]

[[Category: Sacchettini, J.C.]]

[[Category: Sacchettini, J C.]]

[[Category: Savva, C.G.]]

[[Category: Savva, C G.]]

[[Category: Sharma, V.]]

[[Category: TBSGC, TB.Structural.Genomics.Consortium.]]

[[Category: TBSGC, TB Structural Genomics Consortium.]]

[[Category: atpase]]

[[Category: helicase-like motor domain]]

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[[Category: transmembrane transport]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 22~~:21:~~24 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:07:16 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1nl3.gif|left|200px]]<br /><applet load="1nl3" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1nl3.gif|left|200px]]<br /><applet load="1nl3" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1nl3, resolution 2.800&Aring;" />
 '''CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM'''<br />
 ==Overview==
-In bacteria, the majority of exported proteins are translocated by the Sec, system, which recognizes the signal sequence of a preprotein and uses ATP, and the proton motive force to mediate protein translocation across the, cytoplasmic membrane. SecA is an essential protein component of this, system, containing the molecular motor that facilitates translocation., Here we report the three-dimensional structure of the SecA protein of, Mycobacterium tuberculosis. Each subunit of the homodimer contains a, "motor" domain and a translocation domain. The structure predicts that, SecA can interact with the SecYEG pore and function as a molecular ratchet, that uses ATP hydrolysis for physical movement of the preprotein., Knowledge of this structure provides a framework for further elucidation, of the translocation process.
+In bacteria, the majority of exported proteins are translocated by the Sec system, which recognizes the signal sequence of a preprotein and uses ATP and the proton motive force to mediate protein translocation across the cytoplasmic membrane. SecA is an essential protein component of this system, containing the molecular motor that facilitates translocation. Here we report the three-dimensional structure of the SecA protein of Mycobacterium tuberculosis. Each subunit of the homodimer contains a "motor" domain and a translocation domain. The structure predicts that SecA can interact with the SecYEG pore and function as a molecular ratchet that uses ATP hydrolysis for physical movement of the preprotein. Knowledge of this structure provides a framework for further elucidation of the translocation process.
 ==About this Structure==
-NL3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NL3 OCA].
+NL3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NL3 OCA].
 ==Reference==
@@ Line 16: / Line 16: @@
 [[Category: Braunstein, M.]]
 [[Category: Holzenburg, A.]]
-[[Category: Jr., W.R.Jacobs.]]
+[[Category: Jr., W R.Jacobs.]]
-[[Category: Ronning, D.R.]]
+[[Category: Ronning, D R.]]
-[[Category: Sacchettini, J.C.]]
+[[Category: Sacchettini, J C.]]
-[[Category: Savva, C.G.]]
+[[Category: Savva, C G.]]
 [[Category: Sharma, V.]]
-[[Category: TBSGC, TB.Structural.Genomics.Consortium.]]
+[[Category: TBSGC, TB Structural Genomics Consortium.]]
 [[Category: atpase]]
 [[Category: helicase-like motor domain]]
@@ Line 32: / Line 32: @@
 [[Category: transmembrane transport]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:21:24 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:07:16 2008''