1nz9: Difference between revisions
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New page: left|200px<br /><applet load="1nz9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nz9" /> '''Solution Structure of the N-utilisation subs... |
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[[Image:1nz9.jpg|left|200px]]<br /><applet load="1nz9" size=" | [[Image:1nz9.jpg|left|200px]]<br /><applet load="1nz9" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1nz9" /> | caption="1nz9" /> | ||
'''Solution Structure of the N-utilisation substance G (NusG) C-terminal (NGC) domain from Thermus thermophilus'''<br /> | '''Solution Structure of the N-utilisation substance G (NusG) C-terminal (NGC) domain from Thermus thermophilus'''<br /> | ||
==Overview== | ==Overview== | ||
NusG is an essential bacterial protein modulator of transcriptional | NusG is an essential bacterial protein modulator of transcriptional elongation and termination events, and interacts directly with RNA polymerase and Rho protein. Found also in Archaea, NusG shows stretches of sequence similarity to the eukaryotic transcription elongation factor Spt5. Herein, the three-dimensional solution structure of the bacterial NusG from Thermus thermophilus, which shows 43% amino acid sequence similarity to the Escherichia coli NusG, is described, and a survey of NusG and Spt5 amino acid sequences is presented. Although there is a clear evolutionary and functional relationship between these proteins, it is evident from the structural, sequence, and biochemical data that their binding specificities to both nucleic acids and other proteins differ. | ||
==About this Structure== | ==About this Structure== | ||
1NZ9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http:// | 1NZ9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZ9 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
[[Category: Kuramitsu, S.]] | [[Category: Kuramitsu, S.]] | ||
[[Category: RSGI, RIKEN | [[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]] | ||
[[Category: Reay, P.]] | [[Category: Reay, P.]] | ||
[[Category: Shirouzu, M.]] | [[Category: Shirouzu, M.]] | ||
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[[Category: transcription elongation]] | [[Category: transcription elongation]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:11:42 2008'' | ||
