2iko: Difference between revisions

Revision as of 13:54, 17 February 2009

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2iko.png

2iko, resolution 1.90Å (default scene)

Ligands:

7IG

Gene:

REN (Homo sapiens)

Activity:

Renin, with EC number 3.4.23.15

Structural annotation:
Resources:	InterPro : Ipr009007, Ipr001461, Ipr012848, Ipr001969 Pfam : PF00026 UniProt : P00797

Functional annotation:
Cellular component:	extracellular space membrane
Biological process:	regulation of MAPKKK cascade regulation of blood pressure proteolysis angiotensin maturation
Molecular function:	hydrolase activity peptidase activity pepsin A activity renin activity receptor binding aspartic-type endopeptidase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Crystal Structure of Human Renin Complexed with Inhibitor

Template:ABSTRACT PUBMED 17113558

Disease

Known disease associated with this structure: Renal tubular dysgenesis OMIM:[179820], Hyperproreninemia OMIM:[179820]

About this Structure

2IKO is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Sarver RW, Peevers J, Cody WL, Ciske FL, Dyer J, Emerson SD, Hagadorn JC, Holsworth DD, Jalaie M, Kaufman M, Mastronardi M, McConnell P, Powell NA, Quin J 3rd, Van Huis CA, Zhang E, Mochalkin I. Binding thermodynamics of substituted diaminopyrimidine renin inhibitors. Anal Biochem. 2007 Jan 1;360(1):30-40. Epub 2006 Oct 30. PMID:17113558 doi:https://dx.doi.org/10.1016/j.ab.2006.10.017

Page seeded by OCA on Tue Feb 17 15:54:58 2009

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Sarver RW, Peevers J, Cody WL, Ciske FL, Dyer J, Emerson SD, Hagadorn JC, Holsworth DD, Jalaie M, Kaufman M, Mastronardi M, McConnell P, Powell NA, Quin J 3rd, Van Huis CA, Zhang E, Mochalkin I. Binding thermodynamics of substituted diaminopyrimidine renin inhibitors. Anal Biochem. 2007 Jan 1;360(1):30-40. Epub 2006 Oct 30. PMID:17113558 doi:https://dx.doi.org/10.1016/j.ab.2006.10.017

@@ Line 23: / Line 23: @@
 ==About this Structure==
-IKO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IKO OCA].
+IKO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IKO OCA].
 ==Reference==
-Binding thermodynamics of substituted diaminopyrimidine renin inhibitors., Sarver RW, Peevers J, Cody WL, Ciske FL, Dyer J, Emerson SD, Hagadorn JC, Holsworth DD, Jalaie M, Kaufman M, Mastronardi M, McConnell P, Powell NA, Quin J 3rd, Van Huis CA, Zhang E, Mochalkin I, Anal Biochem. 2007 Jan 1;360(1):30-40. Epub 2006 Oct 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17113558 17113558]
+<ref group="xtra">PMID:17113558</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
 [[Category: Renin]]
-[[Category: Single protein]]
 [[Category: Mochalkin, I.]]
 [[Category: Drug design]]
@@ Line 35: / Line 34: @@
 [[Category: Renin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:42:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:54:58 2009''

2iko: Difference between revisions

Revision as of 13:54, 17 February 2009

Contents

Crystal Structure of Human Renin Complexed with Inhibitor

Disease

About this Structure

Reference

Proteopedia Page Contributors and Editors (what is this?)

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