2dpr: Difference between revisions
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{{STRUCTURE_2dpr| PDB=2dpr | SCENE= }} | {{STRUCTURE_2dpr| PDB=2dpr | SCENE= }} | ||
===The crystal structures of the calcium-bound con-G and con-T(K7Glu) dimeric peptides demonstrate a novel metal-dependent helix-forming motif=== | |||
{{ABSTRACT_PUBMED_17243678}} | |||
== | ==Function== | ||
[[http://www.uniprot.org/uniprot/CKT_CONTU CKT_CONTU]] Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin inhibits both NR2A and NR2B subunits of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons. Induces sleep-like symptoms in young mice and hyperactivity in older mice.<ref>PMID:2165278</ref> | |||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DPR OCA]. | [[2dpr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DPR OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017243678</ref><references group="xtra"/><references/> | |||
[[Category: Castellino, F J.]] | [[Category: Castellino, F J.]] | ||
[[Category: Cnudde, S E.]] | [[Category: Cnudde, S E.]] | ||
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[[Category: Conantoxin]] | [[Category: Conantoxin]] | ||
[[Category: Gla-containing]] | [[Category: Gla-containing]] | ||
[[Category: Metal binding protein]] | |||
[[Category: Nmdar antagonist]] | [[Category: Nmdar antagonist]] | ||
Revision as of 11:30, 24 July 2013
The crystal structures of the calcium-bound con-G and con-T(K7Glu) dimeric peptides demonstrate a novel metal-dependent helix-forming motif
Template:ABSTRACT PUBMED 17243678
Function
[CKT_CONTU] Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin inhibits both NR2A and NR2B subunits of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons. Induces sleep-like symptoms in young mice and hyperactivity in older mice.[1]
About this Structure
2dpr is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Cnudde SE, Prorok M, Dai Q, Castellino FJ, Geiger JH. The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif. J Am Chem Soc. 2007 Feb 14;129(6):1586-93. Epub 2007 Jan 23. PMID:17243678 doi:10.1021/ja065722q
