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| [[Image:2p4t.png|left|200px]] | | [[Image:2p4t.png|left|200px]] |
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| ==About this Structure== | | ==About this Structure== |
| 2P4T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4T OCA].
| | [[2p4t]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4T OCA]. |
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| | ==See Also== |
| | *[[Dihydrofolate reductase]] |
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| ==Reference== | | ==Reference== |
| Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode., Divya N, Grifith E, Narayana N, Protein Sci. 2007 Jun;16(6):1063-8. Epub 2007 May 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17473013 17473013]
| | <ref group="xtra">PMID:17473013</ref><ref group="xtra">PMID:16790925</ref><ref group="xtra">PMID:7583655</ref><ref group="xtra">PMID:9543003</ref><references group="xtra"/> |
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| High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D2-symmetric active site., Narayana N, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):695-706. Epub 2006, Jun 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16790925 16790925]
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| A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site., Narayana N, Matthews DA, Howell EE, Nguyen-huu X, Nat Struct Biol. 1995 Nov;2(11):1018-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7583655 7583655]
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| A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition., Park H, Bradrick TD, Howell EE, Protein Eng. 1997 Dec;10(12):1415-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9543003 9543003]
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| [[Category: Dihydrofolate reductase]] | | [[Category: Dihydrofolate reductase]] |
| [[Category: Escherichia coli]] | | [[Category: Escherichia coli]] |
| [[Category: Single protein]]
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| [[Category: Divya, N.]] | | [[Category: Divya, N.]] |
| [[Category: Grifith, E.]] | | [[Category: Grifith, E.]] |
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| [[Category: Symmetric binding]] | | [[Category: Symmetric binding]] |
| [[Category: Trimethoprim-resistance]] | | [[Category: Trimethoprim-resistance]] |
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:31:20 2008''
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