1p1z: Difference between revisions

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[[Image:1p1z.gif|left|200px]]<br /><applet load="1p1z" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1p1z.gif|left|200px]]<br /><applet load="1p1z" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1p1z, resolution 3.26Å" />

'''X-RAY CRYSTAL STRUCTURE OF THE LECTIN-LIKE NATURAL KILLER CELL RECEPTOR LY-49C BOUND TO ITS MHC CLASS I LIGAND H-2Kb'''<br />

==Overview==

The Ly49 family of natural killer (NK) receptors regulates NK cell, function by sensing major histocompatibility complex (MHC) class I. Ly49, receptors show complex patterns of MHC class I cross-reactivity and, in, certain cases, peptide selectivity. To investigate whether specificity, differences result from topological differences in MHC class I engagement, we determined the structure of the peptide-selective receptor Ly49C in, complex with H-2K(b). The Ly49C homodimer binds two MHC class I molecules, in symmetrical way, a mode distinct from that of Ly49A, which binds MHC, class I asymmetrically. Ly49C does not directly contact the MHC-bound, peptide. In addition, MHC crosslinking by Ly49C was demonstrated in, solution. We propose a dynamic model for Ly49-MHC class I interactions, involving conformational changes in the receptor, whereby variations in, Ly49 dimerization mediate different MHC-binding modes.

The Ly49 family of natural killer (NK) receptors regulates NK cell function by sensing major histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC class I cross-reactivity and, in certain cases, peptide selectivity. To investigate whether specificity differences result from topological differences in MHC class I engagement, we determined the structure of the peptide-selective receptor Ly49C in complex with H-2K(b). The Ly49C homodimer binds two MHC class I molecules in symmetrical way, a mode distinct from that of Ly49A, which binds MHC class I asymmetrically. Ly49C does not directly contact the MHC-bound peptide. In addition, MHC crosslinking by Ly49C was demonstrated in solution. We propose a dynamic model for Ly49-MHC class I interactions involving conformational changes in the receptor, whereby variations in Ly49 dimerization mediate different MHC-binding modes.

==About this Structure==

1P1Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1P1Z OCA].

1P1Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P1Z OCA].

==Reference==

Line 15:

[[Category: Dam, J.]]

[[Category: Dimasi, N.]]

[[Category: Margulies, D.H.]]

[[Category: Margulies, D H.]]

[[Category: Mariuzza, R.A.]]

[[Category: Mariuzza, R A.]]

[[Category: Natarajan, K.]]

[[Category: Rangjin, G.]]

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[[Category: ova]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 23~~:23:~~56 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:24:14 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1p1z.gif|left|200px]]<br /><applet load="1p1z" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1p1z.gif|left|200px]]<br /><applet load="1p1z" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1p1z, resolution 3.26&Aring;" />
 '''X-RAY CRYSTAL STRUCTURE OF THE LECTIN-LIKE NATURAL KILLER CELL RECEPTOR LY-49C BOUND TO ITS MHC CLASS I LIGAND H-2Kb'''<br />
 ==Overview==
-The Ly49 family of natural killer (NK) receptors regulates NK cell, function by sensing major histocompatibility complex (MHC) class I. Ly49, receptors show complex patterns of MHC class I cross-reactivity and, in, certain cases, peptide selectivity. To investigate whether specificity, differences result from topological differences in MHC class I engagement, we determined the structure of the peptide-selective receptor Ly49C in, complex with H-2K(b). The Ly49C homodimer binds two MHC class I molecules, in symmetrical way, a mode distinct from that of Ly49A, which binds MHC, class I asymmetrically. Ly49C does not directly contact the MHC-bound, peptide. In addition, MHC crosslinking by Ly49C was demonstrated in, solution. We propose a dynamic model for Ly49-MHC class I interactions, involving conformational changes in the receptor, whereby variations in, Ly49 dimerization mediate different MHC-binding modes.
+The Ly49 family of natural killer (NK) receptors regulates NK cell function by sensing major histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC class I cross-reactivity and, in certain cases, peptide selectivity. To investigate whether specificity differences result from topological differences in MHC class I engagement, we determined the structure of the peptide-selective receptor Ly49C in complex with H-2K(b). The Ly49C homodimer binds two MHC class I molecules in symmetrical way, a mode distinct from that of Ly49A, which binds MHC class I asymmetrically. Ly49C does not directly contact the MHC-bound peptide. In addition, MHC crosslinking by Ly49C was demonstrated in solution. We propose a dynamic model for Ly49-MHC class I interactions involving conformational changes in the receptor, whereby variations in Ly49 dimerization mediate different MHC-binding modes.
 ==About this Structure==
-P1Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1P1Z OCA].
+P1Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P1Z OCA].
 ==Reference==
@@ Line 15: / Line 15: @@
 [[Category: Dam, J.]]
 [[Category: Dimasi, N.]]
-[[Category: Margulies, D.H.]]
+[[Category: Margulies, D H.]]
-[[Category: Mariuzza, R.A.]]
+[[Category: Mariuzza, R A.]]
 [[Category: Natarajan, K.]]
 [[Category: Rangjin, G.]]
@@ Line 26: / Line 26: @@
 [[Category: ova]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:23:56 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:24:14 2008''