1p39: Difference between revisions
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New page: left|200px<br /><applet load="1p39" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p39, resolution 2.0Å" /> '''DC26 MUTANT OF VACCIN... |
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[[Image:1p39.jpg|left|200px]]<br /><applet load="1p39" size=" | [[Image:1p39.jpg|left|200px]]<br /><applet load="1p39" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1p39, resolution 2.0Å" /> | caption="1p39, resolution 2.0Å" /> | ||
'''DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG'''<br /> | '''DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG'''<br /> | ||
==Overview== | ==Overview== | ||
The specific binding of N7-methylguanine cap analogues to the RNA | The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap. | ||
==About this Structure== | ==About this Structure== | ||
1P39 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus] with SAH and MGT as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] Full crystallographic information is available from [http:// | 1P39 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus] with <scene name='pdbligand=SAH:'>SAH</scene> and <scene name='pdbligand=MGT:'>MGT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P39 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
[[Category: Gershon, P | [[Category: Gershon, P D.]] | ||
[[Category: Hodel, A | [[Category: Hodel, A E.]] | ||
[[Category: Quiocho, F | [[Category: Quiocho, F A.]] | ||
[[Category: MGT]] | [[Category: MGT]] | ||
[[Category: SAH]] | [[Category: SAH]] | ||
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[[Category: vaccinia]] | [[Category: vaccinia]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:24:38 2008'' | ||
