1pid: Difference between revisions

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[[Image:1pid.gif|left|200px]]<br /><applet load="1pid" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1pid.gif|left|200px]]<br /><applet load="1pid" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1pid, resolution 1.3Å" />

'''BOVINE DESPENTAPEPTIDE INSULIN'''<br />

==Overview==

The crystal structure of despentapeptide insulin, a monomeric insulin, has, been refined at 1.3 A spacing and subsequently used to predict and model, the organization in the insulin fibril. The model makes use of the, contacts in the densely packed despentapeptide insulin crystal, and takes, into account other experimental evidence, including binding studies with, Congo red. The dimensions of this model fibril correspond well with those, measured experimentally, and the monomer-monomer contacts within the, fibril are in accordance with the known physical chemistry of insulin, fibrils. Using this model, it may be possible to predict mutations in, insulin that might alleviate problems associated with fibril formation, during insulin therapy.

The crystal structure of despentapeptide insulin, a monomeric insulin, has been refined at 1.3 A spacing and subsequently used to predict and model the organization in the insulin fibril. The model makes use of the contacts in the densely packed despentapeptide insulin crystal, and takes into account other experimental evidence, including binding studies with Congo red. The dimensions of this model fibril correspond well with those measured experimentally, and the monomer-monomer contacts within the fibril are in accordance with the known physical chemistry of insulin fibrils. Using this model, it may be possible to predict mutations in insulin that might alleviate problems associated with fibril formation during insulin therapy.

==About this Structure==

1PID is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1PID OCA].

1PID is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PID OCA].

==Reference==

Line 13:

[[Category: Bos taurus]]

[[Category: Protein complex]]

[[Category: Dodson, G.G.]]

[[Category: Dodson, G G.]]

[[Category: Holden, P.H.]]

[[Category: Holden, P H.]]

[[Category: Papiz, M.]]

[[Category: glucose metabolism]]

[[Category: hormone]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 23~~:50:~~11 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:29:05 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1pid.gif|left|200px]]<br /><applet load="1pid" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1pid.gif|left|200px]]<br /><applet load="1pid" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1pid, resolution 1.3&Aring;" />
 '''BOVINE DESPENTAPEPTIDE INSULIN'''<br />
 ==Overview==
-The crystal structure of despentapeptide insulin, a monomeric insulin, has, been refined at 1.3 A spacing and subsequently used to predict and model, the organization in the insulin fibril. The model makes use of the, contacts in the densely packed despentapeptide insulin crystal, and takes, into account other experimental evidence, including binding studies with, Congo red. The dimensions of this model fibril correspond well with those, measured experimentally, and the monomer-monomer contacts within the, fibril are in accordance with the known physical chemistry of insulin, fibrils. Using this model, it may be possible to predict mutations in, insulin that might alleviate problems associated with fibril formation, during insulin therapy.
+The crystal structure of despentapeptide insulin, a monomeric insulin, has been refined at 1.3 A spacing and subsequently used to predict and model the organization in the insulin fibril. The model makes use of the contacts in the densely packed despentapeptide insulin crystal, and takes into account other experimental evidence, including binding studies with Congo red. The dimensions of this model fibril correspond well with those measured experimentally, and the monomer-monomer contacts within the fibril are in accordance with the known physical chemistry of insulin fibrils. Using this model, it may be possible to predict mutations in insulin that might alleviate problems associated with fibril formation during insulin therapy.
 ==About this Structure==
-PID is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PID OCA].
+PID is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PID OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Bos taurus]]
 [[Category: Protein complex]]
-[[Category: Dodson, G.G.]]
+[[Category: Dodson, G G.]]
-[[Category: Holden, P.H.]]
+[[Category: Holden, P H.]]
 [[Category: Papiz, M.]]
 [[Category: glucose metabolism]]
 [[Category: hormone]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:50:11 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:29:05 2008''