1pto: Difference between revisions

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[[Image:1pto.jpg|left|200px]]<br /><applet load="1pto" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1pto.jpg|left|200px]]<br /><applet load="1pto" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1pto, resolution 3.5Å" />

'''THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING'''<br />

==Overview==

Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis, which is important the pathogenesis of whooping cough and the generation, of a protective immune response. The diverse biological activities of the, toxin depend on its ability to recognize carbohydrate-containing receptors, on a wide variety of eukaryotic cells. We present here the crystal, structure of pertussis toxin complexed with a soluble oligosaccharide from, transferrin. Binding sites for the terminal sialic acid-galactose moiety, are revealed on both subunits S2 and S3 of the B-oligomer. Identification, of amino acid residues involved in receptor binding will improve the, design of genetically inactivated toxins for use in new acellular whooping, cough vaccines.

Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis which is important the pathogenesis of whooping cough and the generation of a protective immune response. The diverse biological activities of the toxin depend on its ability to recognize carbohydrate-containing receptors on a wide variety of eukaryotic cells. We present here the crystal structure of pertussis toxin complexed with a soluble oligosaccharide from transferrin. Binding sites for the terminal sialic acid-galactose moiety are revealed on both subunits S2 and S3 of the B-oligomer. Identification of amino acid residues involved in receptor binding will improve the design of genetically inactivated toxins for use in new acellular whooping cough vaccines.

==About this Structure==

1PTO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1PTO OCA].

1PTO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PTO OCA].

==Reference==

Line 13:

[[Category: Bordetella pertussis]]

[[Category: Protein complex]]

[[Category: Read, R.J.]]

[[Category: Read, R J.]]

[[Category: Stein, P.E.]]

[[Category: Stein, P E.]]

[[Category: toxin]]

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@@ Line 1: / Line 1: @@
-[[Image:1pto.jpg|left|200px]]<br /><applet load="1pto" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1pto.jpg|left|200px]]<br /><applet load="1pto" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1pto, resolution 3.5&Aring;" />
 '''THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING'''<br />
 ==Overview==
-Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis, which is important the pathogenesis of whooping cough and the generation, of a protective immune response. The diverse biological activities of the, toxin depend on its ability to recognize carbohydrate-containing receptors, on a wide variety of eukaryotic cells. We present here the crystal, structure of pertussis toxin complexed with a soluble oligosaccharide from, transferrin. Binding sites for the terminal sialic acid-galactose moiety, are revealed on both subunits S2 and S3 of the B-oligomer. Identification, of amino acid residues involved in receptor binding will improve the, design of genetically inactivated toxins for use in new acellular whooping, cough vaccines.
+Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis which is important the pathogenesis of whooping cough and the generation of a protective immune response. The diverse biological activities of the toxin depend on its ability to recognize carbohydrate-containing receptors on a wide variety of eukaryotic cells. We present here the crystal structure of pertussis toxin complexed with a soluble oligosaccharide from transferrin. Binding sites for the terminal sialic acid-galactose moiety are revealed on both subunits S2 and S3 of the B-oligomer. Identification of amino acid residues involved in receptor binding will improve the design of genetically inactivated toxins for use in new acellular whooping cough vaccines.
 ==About this Structure==
-PTO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PTO OCA].
+PTO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PTO OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Bordetella pertussis]]
 [[Category: Protein complex]]
-[[Category: Read, R.J.]]
+[[Category: Read, R J.]]
-[[Category: Stein, P.E.]]
+[[Category: Stein, P E.]]
 [[Category: toxin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:07:06 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:32:25 2008''