1ptr: Difference between revisions
New page: left|200px<br /><applet load="1ptr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ptr, resolution 2.2Å" /> '''PROTEIN KINASE C DELT... |
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[[Image:1ptr.gif|left|200px]]<br /><applet load="1ptr" size=" | [[Image:1ptr.gif|left|200px]]<br /><applet load="1ptr" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1ptr, resolution 2.2Å" /> | caption="1ptr, resolution 2.2Å" /> | ||
'''PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE'''<br /> | '''PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE'''<br /> | ||
==Overview== | ==Overview== | ||
Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes | Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes that associate with membranes and are activated by diacylglycerol or tumor-promoting agonists such as phorbol esters. The structure of the second activator-binding domain of PKC delta has been determined in complex with phorbol 13-acetate, which binds in a groove between two pulled-apart beta strands at the tip of the domain. The C3, C4, and C20 phorbol oxygens form hydrogen bonds with main-chain groups whose orientation is controlled by a set of highly conserved residues. Phorbol binding caps the groove and forms a contiguous hydrophobic surface covering one-third of the domain, explaining how the activator promotes insertion of PKC into membranes. | ||
==About this Structure== | ==About this Structure== | ||
1PTR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ZN and PRB as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1PTR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=PRB:'>PRB</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PTR OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hurley, J | [[Category: Hurley, J H.]] | ||
[[Category: Zhang, G.]] | [[Category: Zhang, G.]] | ||
[[Category: PRB]] | [[Category: PRB]] | ||
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[[Category: phosphotransferase]] | [[Category: phosphotransferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:32:31 2008'' | ||
Revision as of 12:32, 21 February 2008
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PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE
Overview
Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes that associate with membranes and are activated by diacylglycerol or tumor-promoting agonists such as phorbol esters. The structure of the second activator-binding domain of PKC delta has been determined in complex with phorbol 13-acetate, which binds in a groove between two pulled-apart beta strands at the tip of the domain. The C3, C4, and C20 phorbol oxygens form hydrogen bonds with main-chain groups whose orientation is controlled by a set of highly conserved residues. Phorbol binding caps the groove and forms a contiguous hydrophobic surface covering one-third of the domain, explaining how the activator promotes insertion of PKC into membranes.
About this Structure
1PTR is a Single protein structure of sequence from Mus musculus with ZN and PRB as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester., Zhang G, Kazanietz MG, Blumberg PM, Hurley JH, Cell. 1995 Jun 16;81(6):917-24. PMID:7781068
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