2o8e: Difference between revisions

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==About this Structure==
==About this Structure==
2O8E is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8E OCA].  
2O8E is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8E OCA].  


==Reference==
==Reference==
Structure of the human MutSalpha DNA lesion recognition complex., Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS, Mol Cell. 2007 May 25;26(4):579-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17531815 17531815]
<ref group="xtra">PMID:17531815</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Beese, L S.]]
[[Category: Beese, L S.]]
[[Category: Changela, A.]]
[[Category: Changela, A.]]
Line 42: Line 41:
[[Category: Somatic hypermutation]]
[[Category: Somatic hypermutation]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:14:05 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:31:52 2009''

Revision as of 03:31, 18 February 2009

File:2o8e.png

Template:STRUCTURE 2o8e

human MutSalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only

Template:ABSTRACT PUBMED 17531815

Disease

Known disease associated with this structure: Colorectal cancer, hereditary nonpolyposis, type 1 OMIM:[609309], Mismatch repair cancer syndrome OMIM:[609309], Muir-Torre syndrome OMIM:[609309]

About this Structure

2O8E is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS. Structure of the human MutSalpha DNA lesion recognition complex. Mol Cell. 2007 May 25;26(4):579-92. PMID:17531815 doi:10.1016/j.molcel.2007.04.018

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