1qd9: Difference between revisions

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[[Image:1qd9.gif|left|200px]]<br /><applet load="1qd9" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1qd9.gif|left|200px]]<br /><applet load="1qd9" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1qd9, resolution 1.70Å" />

'''Bacillus subtilis YABJ'''<br />

==Overview==

The yabJ gene in Bacillus subtilis is required for adenine-mediated, repression of purine biosynthetic genes in vivo and codes for an, acid-soluble, 14-kDa protein. The molecular mechanism of YabJ is unknown., YabJ is a member of a large, widely distributed family of proteins of, unknown biochemical function. The 1.7-A crystal structure of YabJ reveals, a trimeric organization with extensive buried hydrophobic surface and an, internal water-filled cavity. The most important finding in the structure, is a deep, narrow cleft between subunits lined with nine side chains that, are invariant among the 25 most similar homologs. This conserved site is, proposed to be a binding or catalytic site for a ligand or substrate that, is common to YabJ and other members of the YER057c/YjgF/UK114 family of, proteins.

The yabJ gene in Bacillus subtilis is required for adenine-mediated repression of purine biosynthetic genes in vivo and codes for an acid-soluble, 14-kDa protein. The molecular mechanism of YabJ is unknown. YabJ is a member of a large, widely distributed family of proteins of unknown biochemical function. The 1.7-A crystal structure of YabJ reveals a trimeric organization with extensive buried hydrophobic surface and an internal water-filled cavity. The most important finding in the structure is a deep, narrow cleft between subunits lined with nine side chains that are invariant among the 25 most similar homologs. This conserved site is proposed to be a binding or catalytic site for a ligand or substrate that is common to YabJ and other members of the YER057c/YjgF/UK114 family of proteins.

==About this Structure==

1QD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with HG, EMC and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1QD9 OCA].

1QD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=HG:'>HG</scene>, <scene name='pdbligand=EMC:'>EMC</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QD9 OCA].

==Reference==

Line 13:

[[Category: Bacillus subtilis]]

[[Category: Single protein]]

[[Category: Lange, S.C.]]

[[Category: Lange, S C.]]

[[Category: Mantsala, P.]]

[[Category: Rappu, P.]]

[[Category: Sinha, S.]]

[[Category: Smith, J.L.]]

[[Category: Smith, J L.]]

[[Category: Zalkin, H.]]

[[Category: ACY]]

Line 27:

[[Category: yjgf/yer057c family]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 00:35:~~35 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:24 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1qd9.gif|left|200px]]<br /><applet load="1qd9" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1qd9.gif|left|200px]]<br /><applet load="1qd9" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1qd9, resolution 1.70&Aring;" />
 '''Bacillus subtilis YABJ'''<br />
 ==Overview==
-The yabJ gene in Bacillus subtilis is required for adenine-mediated, repression of purine biosynthetic genes in vivo and codes for an, acid-soluble, 14-kDa protein. The molecular mechanism of YabJ is unknown., YabJ is a member of a large, widely distributed family of proteins of, unknown biochemical function. The 1.7-A crystal structure of YabJ reveals, a trimeric organization with extensive buried hydrophobic surface and an, internal water-filled cavity. The most important finding in the structure, is a deep, narrow cleft between subunits lined with nine side chains that, are invariant among the 25 most similar homologs. This conserved site is, proposed to be a binding or catalytic site for a ligand or substrate that, is common to YabJ and other members of the YER057c/YjgF/UK114 family of, proteins.
+The yabJ gene in Bacillus subtilis is required for adenine-mediated repression of purine biosynthetic genes in vivo and codes for an acid-soluble, 14-kDa protein. The molecular mechanism of YabJ is unknown. YabJ is a member of a large, widely distributed family of proteins of unknown biochemical function. The 1.7-A crystal structure of YabJ reveals a trimeric organization with extensive buried hydrophobic surface and an internal water-filled cavity. The most important finding in the structure is a deep, narrow cleft between subunits lined with nine side chains that are invariant among the 25 most similar homologs. This conserved site is proposed to be a binding or catalytic site for a ligand or substrate that is common to YabJ and other members of the YER057c/YjgF/UK114 family of proteins.
 ==About this Structure==
-QD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with HG, EMC and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QD9 OCA].
+QD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=HG:'>HG</scene>, <scene name='pdbligand=EMC:'>EMC</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QD9 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Bacillus subtilis]]
 [[Category: Single protein]]
-[[Category: Lange, S.C.]]
+[[Category: Lange, S C.]]
 [[Category: Mantsala, P.]]
 [[Category: Rappu, P.]]
 [[Category: Sinha, S.]]
-[[Category: Smith, J.L.]]
+[[Category: Smith, J L.]]
 [[Category: Zalkin, H.]]
 [[Category: ACY]]
@@ Line 27: / Line 27: @@
 [[Category: yjgf/yer057c family]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:35:35 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:24 2008''