1qf4: Difference between revisions

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[[Image:1qf4.jpg|left|200px]]<br /><applet load="1qf4" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1qf4.jpg|left|200px]]<br /><applet load="1qf4" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1qf4, resolution 2.2Å" />

'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''<br />

==Overview==

Two relatively weak herbicides, hydantocidin phosphate and hadacidin were, linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is, shown) of the enzyme adenylosuccinate synthetase. The crystal structures, of the bisubstrate-enzyme complexes were determined.

Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.

==About this Structure==

1QF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with PO4, MG, GDP and RPD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1QF4 OCA].

1QF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=GDP:'>GDP</scene> and <scene name='pdbligand=RPD:'>RPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF4 OCA].

==Reference==

Line 15:

[[Category: Single protein]]

[[Category: Chemla, P.]]

[[Category: Cowan-Jacob, S.W.]]

[[Category: Cowan-Jacob, S W.]]

[[Category: Fonne-Pfister, R.]]

[[Category: Gohda, K.]]

[[Category: Hanessian, S.]]

[[Category: Lu, P.P.]]

[[Category: Lu, P P.]]

[[Category: Prade, L.]]

[[Category: Sanceau, J.Y.]]

[[Category: Sanceau, J Y.]]

[[Category: GDP]]

[[Category: MG]]

Line 31:

[[Category: synthetase]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 00:37:~~37 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:49 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1qf4.jpg|left|200px]]<br /><applet load="1qf4" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1qf4.jpg|left|200px]]<br /><applet load="1qf4" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1qf4, resolution 2.2&Aring;" />
 '''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''<br />
 ==Overview==
-Two relatively weak herbicides, hydantocidin phosphate and hadacidin were, linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is, shown) of the enzyme adenylosuccinate synthetase. The crystal structures, of the bisubstrate-enzyme complexes were determined.
+Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.
 ==About this Structure==
-QF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with PO4, MG, GDP and RPD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QF4 OCA].
+QF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=GDP:'>GDP</scene> and <scene name='pdbligand=RPD:'>RPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF4 OCA].
 ==Reference==
@@ Line 15: / Line 15: @@
 [[Category: Single protein]]
 [[Category: Chemla, P.]]
-[[Category: Cowan-Jacob, S.W.]]
+[[Category: Cowan-Jacob, S W.]]
 [[Category: Fonne-Pfister, R.]]
 [[Category: Gohda, K.]]
 [[Category: Hanessian, S.]]
-[[Category: Lu, P.P.]]
+[[Category: Lu, P P.]]
 [[Category: Prade, L.]]
-[[Category: Sanceau, J.Y.]]
+[[Category: Sanceau, J Y.]]
 [[Category: GDP]]
 [[Category: MG]]
@@ Line 31: / Line 31: @@
 [[Category: synthetase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:37:37 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:38:49 2008''