1qqe: Difference between revisions

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[[Image:1qqe.gif|left|200px]]<br /><applet load="1qqe" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1qqe.gif|left|200px]]<br /><applet load="1qqe" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1qqe, resolution 2.90Å" />

'''CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17'''<br />

==Overview==

SNAP proteins play an essential role in membrane trafficking in eukaryotic, cells. They activate and recycle SNARE proteins by serving as adaptors, between SNAREs and the cytosolic chaperone NSF. We have determined the, crystal structure of Sec17, the yeast homolog of alpha-SNAP, to 2.9 A, resolution. Sec17 is composed of an N-terminal twisted sheet of, alpha-helical hairpins and a C-terminal alpha-helical bundle. The, N-terminal sheet has local similarity to the tetratricopeptide repeats, from protein phosphatase 5 but has a different overall twist. Sec17 also, shares structural features with HEAT and clathrin heavy chain repeats., Possible models of SNAP:SNARE binding suggest that SNAPs may function as, lever arms, transmitting forces generated by conformational changes in, NSF/Sec18 to drive disassembly of SNARE complexes.

SNAP proteins play an essential role in membrane trafficking in eukaryotic cells. They activate and recycle SNARE proteins by serving as adaptors between SNAREs and the cytosolic chaperone NSF. We have determined the crystal structure of Sec17, the yeast homolog of alpha-SNAP, to 2.9 A resolution. Sec17 is composed of an N-terminal twisted sheet of alpha-helical hairpins and a C-terminal alpha-helical bundle. The N-terminal sheet has local similarity to the tetratricopeptide repeats from protein phosphatase 5 but has a different overall twist. Sec17 also shares structural features with HEAT and clathrin heavy chain repeats. Possible models of SNAP:SNARE binding suggest that SNAPs may function as lever arms, transmitting forces generated by conformational changes in NSF/Sec18 to drive disassembly of SNARE complexes.

==About this Structure==

1QQE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA].

1QQE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA].

==Reference==

Line 13:

[[Category: Saccharomyces cerevisiae]]

[[Category: Single protein]]

[[Category: Brunger, A.T.]]

[[Category: Brunger, A T.]]

[[Category: Rice, L.M.]]

[[Category: Rice, L M.]]

[[Category: helix-turn-helix tpr-like repeat]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 00:53:~~33 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:42:31 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1qqe.gif|left|200px]]<br /><applet load="1qqe" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1qqe.gif|left|200px]]<br /><applet load="1qqe" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1qqe, resolution 2.90&Aring;" />
 '''CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17'''<br />
 ==Overview==
-SNAP proteins play an essential role in membrane trafficking in eukaryotic, cells. They activate and recycle SNARE proteins by serving as adaptors, between SNAREs and the cytosolic chaperone NSF. We have determined the, crystal structure of Sec17, the yeast homolog of alpha-SNAP, to 2.9 A, resolution. Sec17 is composed of an N-terminal twisted sheet of, alpha-helical hairpins and a C-terminal alpha-helical bundle. The, N-terminal sheet has local similarity to the tetratricopeptide repeats, from protein phosphatase 5 but has a different overall twist. Sec17 also, shares structural features with HEAT and clathrin heavy chain repeats., Possible models of SNAP:SNARE binding suggest that SNAPs may function as, lever arms, transmitting forces generated by conformational changes in, NSF/Sec18 to drive disassembly of SNARE complexes.
+SNAP proteins play an essential role in membrane trafficking in eukaryotic cells. They activate and recycle SNARE proteins by serving as adaptors between SNAREs and the cytosolic chaperone NSF. We have determined the crystal structure of Sec17, the yeast homolog of alpha-SNAP, to 2.9 A resolution. Sec17 is composed of an N-terminal twisted sheet of alpha-helical hairpins and a C-terminal alpha-helical bundle. The N-terminal sheet has local similarity to the tetratricopeptide repeats from protein phosphatase 5 but has a different overall twist. Sec17 also shares structural features with HEAT and clathrin heavy chain repeats. Possible models of SNAP:SNARE binding suggest that SNAPs may function as lever arms, transmitting forces generated by conformational changes in NSF/Sec18 to drive disassembly of SNARE complexes.
 ==About this Structure==
-QQE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA].
+QQE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Saccharomyces cerevisiae]]
 [[Category: Single protein]]
-[[Category: Brunger, A.T.]]
+[[Category: Brunger, A T.]]
-[[Category: Rice, L.M.]]
+[[Category: Rice, L M.]]
 [[Category: helix-turn-helix tpr-like repeat]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:53:33 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:42:31 2008''