1qwe: Difference between revisions
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New page: left|200px<br /><applet load="1qwe" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qwe" /> '''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND APP12... |
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[[Image:1qwe.jpg|left|200px]]<br /><applet load="1qwe" size=" | [[Image:1qwe.jpg|left|200px]]<br /><applet load="1qwe" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1qwe" /> | caption="1qwe" /> | ||
'''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND APP12'''<br /> | '''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND APP12'''<br /> | ||
==Overview== | ==Overview== | ||
Two dodecapeptides belonging to distinct classes of Src homology 3 (SH3) | Two dodecapeptides belonging to distinct classes of Src homology 3 (SH3) ligands and selected from biased phage display libraries were used to investigate interactions between a specificity pocket in the Src SH3 domain and ligant residues flanking the proline-rich core. The solution structures of c-Src SH3 complexed with these peptides were solved by NMR. In addition to proline-rich, polyproline type II helix-forming core, the class I and II ligands each possesses a flanking sequence that occupies a large pocket between the RT and n-Src loops of the SH3 domain. Structural and mutational analyses illustrate how the two classes of SH3 ligands exploit a specificity pocket on the receptor differently to increase binding affinity and specificity. | ||
==About this Structure== | ==About this Structure== | ||
1QWE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http:// | 1QWE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWE OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Chiyoshi, K.]] | [[Category: Chiyoshi, K.]] | ||
[[Category: Feng, S.]] | [[Category: Feng, S.]] | ||
[[Category: Rickles, R | [[Category: Rickles, R J.]] | ||
[[Category: Schreiber, S | [[Category: Schreiber, S L.]] | ||
[[Category: class ii ligand complex]] | [[Category: class ii ligand complex]] | ||
[[Category: src sh3 domain]] | [[Category: src sh3 domain]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:44:24 2008'' | ||
